Chapter 21: Problem 6
List and describe three major goals of the Human Genome Project.
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Chapter 21: Problem 6
List and describe three major goals of the Human Genome Project.
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The discovery that \(M .\) genitalium has a genome of \(0.58 \mathrm{Mb}\) and only 470 protein-coding genes has sparked interest in determining the minimum number of genes needed for a living cell. In the search for organisms with smaller and smaller genomes, a new species of Archaea, Nanoarchaeum equitans, was discovered in a high-temperature vent on the ocean floor. This prokaryote has one of the smallest cell sizes ever discovered, and its genome is only about 0.5 Mb. However, organisms such as \(M .\) genitalium, N. equitans, and other microbes with very small genomes are either parasites or symbionts. How does this affect the search for a minimum genome? Should the definition of the minimum genome size for a living cell be redefined?
Describe the human genome in terms of genome size, the percentage of the genome that codes for proteins, how much is composed of repetitive sequences, and how many genes it contains. Describe two other features of the human genome.
Archaea (formerly known as archaebacteria) is one of the three major divisions of living organisms; the other two are eubacteria and eukaryotes. Nanoarchaeum equitans is in the Archaea domain and has one of the smallest genomes known, about 0.5 Mb. How can an organism complete its life cycle with so little genetic material?
What are gene microarrays? How are microarrays used?
Systems biology models the complex networks of interacting genes, proteins, and other molecules that contribute to human genetic diseases, such as cancer, diabetes, and hypertension. These interactomes show the contribution of each piece towards the whole and where diseases overlap, and provide models for drug discovery and development. Describe some tions (Roy et al., 2008 ). In some cases, closely related homologs may engender completely different classes of proteins (enzymes). Consider the 3 D structure of two proteins with 60 percent homology with entirely different functions. Explain how different functions may evolve by discussing the position of the homologous amino acid track, its relation to nonhomologous tracks, and the role that chaperones (Chapter 14) may play in determining protein function. of the differences that might be seen in the interactomes of normal and cancerous cells taken from the same tissue, and explain how these differences could lead to drugs specifically targeted against cancer cells.
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