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Chapter 15: Q15.4-2CC (page 309)

The ABO blood type locus has been mapped on chromosome 9. A father with type AB blood and a mother who has type O blood have a child with trisomy nine and type A blood. Using this information, can you tell in which parent the non-disjunction occurred? Explain your answer. (See Figures 14.11 and 15.13).

Short Answer

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The child has a genotype, namely IAIAi or IAii. The sperm produced from the father has a genotype of IAIA. The egg possesses genotype ii from non-disjunction that occurs during meiosis I or meiosis II.

Step by step solution

01

Description of non-disjunction

The process of failure in the separation of homologous chromosomes or sister chromosomes is known as non-disjunction. There is an occurrence of abnormal chromosomes in the offspring. It can result in certain defective or disorder conditions.

02

Description of trisomy 9

Trisomy 9 is the condition in which the occurrence of additional chromosomes in the chromosomal location is 9. It is a rare condition compared to trisomy 21 in Down syndrome. The survival rate of trisomy 9 is lower.

03

Prediction of non-disjunction in child

The child has trisomy 9 conditions that possess genotypes such as IAIAi or IAii.The sperm produced from the father has a non-disjunction that takes place during paternal meiosis II. The non-disjunction is the process that results in the failure of the separation of chromosomes in a proper condition.

The egg having genotype ii possesses a non-disjunction condition during the process of maternal meiosis I or meiosis II.

Hence, there is a possibility that non-disjunction can take place in the father and mother.

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