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The organic pollutant present in the environment that cannot be degraded is known as dioxin. It is toxic. It can cause several types of diseases in the animal as well as human system.

Dioxin accumulates in the human body via the food chain. An overdose of dioxin can cause failure in the detoxification mechanism of the liver and cause diseases.

Dioxin is a substance that shows activity similar to hormones. It interacts with the cytoplasmic receptor present in the cell. It interacts with the cell's DNA and interferes with the transcription process.

It can also induce mutation and can cause cancer. However, the dioxin component cannot react with the cytoplasmic receptor to cause toxicity in some organisms.

For example, the cytoplasmic receptor of the hamster is not compatible with the dioxin component. So, the hamster is not affected by the dioxin dose. However, a guinea pig can be killed due to the dosage of dioxin.

In the first demonstration, a person suffering from ill-health is selected to check the effect of dioxin exposure. The DNA microarray techniques are used to find out the impact of dioxin in the genes.

In this test, the gene expression of the ill person is determined, and it is compared with the gene expression of the normal person.

The second demonstration is carried out to induce the dioxin dose to the healthy individual. The illness is generated due to over-accumulation of the dioxin. The overdosage of dioxin can cause diseases in healthy individuals.

The second demonstration is challenging because it is unethical to use healthy individuals to induce the disease and study the effect of dioxin.