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Linkage is found between two genes on the chromosomes that are found in closed association. They are more likely to inherit together to the children from their parents. Also, they have fewer chances to be recombinant. There are many genetic tools that are used to find this linkage.

A genetic marker is the marker sequence of DNA in the chromosome for which the location is known. It can be helpful in linking a genetic disease to the gene that produces it. It is used to track the inheritance of a linked gene of a known location.

Recombination is the process of creating variations in the genome that involves crossing over that is a random event. The possibility of crossing over between two loci in a chromosome is proportional to the distance between them.

The genes are called linked when they are in a closed association. Thus when variation in a single nucleotide occurs in a closed link with the disease-associated allele, chances of crossing over between SNP and this allele are very minimized. Thus for finding the presence of an allele, SNP can be used as a genetic marker.