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Epinephrine initiates a signal transduction pathway that produces cyclic AMP(c-AMP) and leads to the breakdown of glycogen to glucose, a significant energy source for cells. But glycogen breakdown is only part of the fight-or-flight response that epinephrine brings about: the overall effect on the body includes an increase in heart rate and alertness, as well as a burst of energy. Given that caffeine blocks the activity of cAMP phosphodiesterase, propose a mechanism by which caffeine ingestion leads to heightened alertness and sleeplessness.

Short Answer

Expert verified

Caffeine is the substance that blocks the activity of the cAMP phosphodiesterase. The blocking of this enzyme increases the activity of the cAMP that in turn increases alertness and sleeplessness.

Step by step solution

01

Description of epinephrine

Epinephrine is the hormone secreted during the condition of stress, fear, and anger conditions. It tends to increase the heart rate, alertness, and excitation of energy. This hormone is secreted in the adrenal medulla.

02

cAMP phosphodiesterase

cAMP is the cyclic adenosine monophosphate. The enzyme phosphodiesterase initiates the cleavage of the cAMP molecules. It mainly acts on the phosphodiester bond present in the c-AMP molecules.

03

Caffeine ingestion

Caffeine ingestion increases the cAMP level as it blocks the enzyme phosphodiesterase, which involves the cleavage of the cAMP. If the cAMP cleavage is stopped, it will maintain the high level of the cAMP.

Epinephrine is the hormone that initiates the synthesis of cyclic AMP. cAMP keeps the mind alert and keeps the person sleepless.

Hence, the high cAMP level maintenance is the reason for the alertness and sleeplessness that occurs due to coffee consumption.

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