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RNA polymerase is an enzyme that assists in the transcription process by copying a DNA sequence into an RNA sequence.

Option (b) is to use pre-mRNAs. Low amounts of a-amanitin have the greatest impact on pre-mRNAs because a-amanitin interacts with RNA polymerase II's bridge helix (a-helix). The a-helix is primarily responsible for the RNA polymerase II's flexibility and mobility. When a-amanitin binds, its flexibility is harmed, and RNA polymerase II translocation is hampered. A-amanitin has no effect on the rate of nucleotide base addition to pre-mRNA or the formation of phosphodiester linkages between bases. As a result, a-amanitin slows down the total rate of transcription synthesis.

A lethal peptide generated by the poisonous mushroom Amanita phalloides, also known as toadstool mushroom or death cap, is option (a) 18s and 28s rRNAsa-amanitin. Because RNA polymerase I is insensitive to a-amanitin in the cellular department of the nucleolus, a-amanitin has no influence on its activity. So RNA polymerase can transcribe DNA in the presence of this poison.

5s rRNAs and tRNAs are option (c). The deadly peptide a-amanitin is produced by the poisonous mushroom Amanita phalloides, sometimes known as toadstool mushroom or death cap. Because it is found in the nucleus of the cell and may transcribe tRNAs, also known as adaptor molecules, RNA polymerase III is somewhat sensitive to this toxin.

Option (d) Other small nucleus RNAs.a-amanitin is a toxic peptide have moderate sensitivity for RNA polymerase III. This is because it is located in nucleus of cell where small nucleus RNAs plays important roles like splicing of pre mRNAs and regulation of transcription factors.