Standard anticoagulant therapy (to prevent blood clots) requires frequent
laboratory monitoring to prevent internal bleeding. A new procedure using
rivaroxaban (riva) was tested because it does not require frequent monitoring.
A randomized trial (Einstein-PE Investigators 2012 ) was carried out, with
standard therapy being randomly assigned to half of 4832 patients and riva
randomly assigned to the other half. A bad result was recurrence of a blood
clot in a vein. Fifty of the 2416 patients on standard therapy had a bad
outcome, and 44 of the 2416 patients on riva had a bad outcome.
a. Test the hypothesis that the proportions of bad results are different for
riva and standard therapy patients. Use a significance level of \(0.05\), and
show all four steps.
b. Using methods leamed in Chapter 7 , estimate the difference between the two
population proportions using a \(95 \%\) confidence interval, and comment on how
it can be used to evaluate the null hypothesis in part a.