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Refer to the accompanying table showing results from a Chembio test for hepatitis Camong HIV-infected patients (based on data from a variety of sources). $$\begin{array}{|l|c|c|} \hline & \text { Positive Test Result } & \text { Negative Test Result } \\ \hline \text { Hepatitis C } & 335 & 10 \\ \hline \text { No Hepatitis C } & 2 & 1153 \\ \hline \end{array}$$ False Positive Find the probability of selecting a subject with a positive test result, given that the subject does not have hepatitis C. Why is this case problematic for test subjects?

Short Answer

Expert verified
The probability is approximately 0.17%. This can lead to unnecessary stress and medical procedures for the subject.

Step by step solution

01

- Identify Total Number of Subjects Without Hepatitis C

From the table, count the number of subjects who do not have Hepatitis C. This includes both those with a positive test result and those with a negative test result. Using the table, the sum is: \[2 (positive) + 1153 (negative) = 1155\] subjects.
02

- Identify Number of False Positives

From the table, find the number of subjects who do not have Hepatitis C but still tested positive. This number is 2.
03

- Calculate the Probability

The probability of selecting a subject with a positive test result given that the subject does not have Hepatitis C is calculated by dividing the number of false positives by the total number of subjects without Hepatitis C.\[ P(\text{Positive Test} | \text{No Hepatitis C}) = \frac{\text{False Positives}}{\text{Total Subjects Without Hepatitis C}} = \frac{2}{1155} \]
04

- Simplify the Probability

Simplify the fraction \[\frac{2}{1155} \]. This evaluates to approximately 0.0017, or 0.17%.
05

- Explanation of Problematic Case

A false positive result can be problematic because it may cause unnecessary anxiety and lead to further invasive and potentially harmful testing, treatment, and follow-up for a disease that the subject does not actually have.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

False Positive
When discussing medical testing, a 'false positive' occurs when a test indicates that someone has a disease or condition when they actually do not. In our given example, the Chembio test for hepatitis C among HIV-infected patients showed 2 subjects who tested positive despite not having hepatitis C. This is significant because false positives can lead to various problems:
  • Unnecessary anxiety and stress for the patient.
  • Additional and possibly invasive follow-up tests.
  • Incorrect treatment that could pose health risks.
Overall, reducing false positives increases the reliability of a medical test and ensures better patient care.
Probability Calculation
Probability helps us understand the likelihood of an event occurring. In our problem, we aim to find the probability of a subject getting a positive test result despite not having hepatitis C.
First, we need to identify the overall number of subjects without hepatitis C, which includes 2 subjects with false positives and 1153 with negative results. Summing these gives us 1155 total non-infected subjects. Next, we calculate the probability using the following formula: \( P(\text{Positive Test} | \text{No Hepatitis C}) = \frac{\text{False Positives}}{\text{Total Subjects Without Hepatitis C}} = \frac{2}{1155} \).
By simplifying, we get approximately 0.0017 or 0.17%. This equation shows that there's a 0.17% chance for a false positive among those who do not have hepatitis C.
Hepatitis C Test Accuracy
Test accuracy in medical exams is crucial. It refers to how well a test can correctly identify the presence or absence of a disease. Accuracy is determined by factors like sensitivity (true positive rate) and specificity (true negative rate). In our data:
  • 335 subjects had hepatitis C and tested positive.
  • 10 had hepatitis C but tested negative.
  • 2 did not have hepatitis C but tested positive (false positives).
  • 1153 did not have hepatitis C and tested negative.
Ideally, a highly accurate test will have high values of true positives and true negatives with minimal false positives and false negatives. In our example, the low number of false positives (2 out of 1155) suggests reasonably good specificity.
Conditional Probability
Conditional probability deals with the likelihood of an event happening given that another event has already occurred. In our case, we calculate the probability of a positive hepatitis C test result given that the subject does not have hepatitis C.
This is noted as \( P(\text{Positive Test} | \text{No Hepatitis C}) \).
It indicates how likely it is to get a misleading positive test due to the test's limitations. The formula used is \( P(\text{A} | \text{B}) = \frac{P(\text{A} \cap \text{B})}{P(\text{B})} \), where
A = Positive Test and B = Not having Hepatitis C.
By including conditional probability in our analyses, we gain deeper insights into test performance and the potential impacts of test results on patients.

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