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• The isoelectric point (pI, pH (I), IEP) is the pH at which a molecule in the statistical mean carries no net electrical charge or is electrically neutral.

• The standard abbreviation for the isoelectric point is pH (I), though pI is also used and is used in this article for brevity.

• In this task we will explain what is wrong with the statement: At its isoelectric point, the charge on all molecules of a particular protein is${}^{\mathbf{0}\mathbf{.}}$

• In this case the average charge would be 0 and every molecule has a different :isoelectric point.

• Therefore, there is no${}^{\mathbf{pH}}$ at which all molecules would have zero charge.

Hence the reason why the following statement at its isoelectric point, the charge on all molecules of a particular protein is${}^{\mathbf{0}}$ is found.