91影视

Robinson annulation is a chemical reaction that results in a ring formation. Robinson annulations reaction forms$伪,尾$ unsaturated cyclic ketones from methyl vinyl ketones and aldehyde or ketones.

Robinson annulation has two reactions: First, Michael reaction and then intramolecular aldol condensation to give a new six-membered ring containing an alpha, beta-unsaturated ketone.

Robinson annulation begins with a Micheal addition followed by aldol condensation:

• Essential condition present, which removes $伪$- proton from ketone.
• In Micheal鈥檚 reaction, the enolate formed attacks enone.
• Enolate protonates to give ketone.
• Base removes$伪$ - proton.
• In an aldol reaction, the enolate attacks the ketone.
• Alkoxide protonates to provide alcohol.
• The command removes -proton, and elimination of hydroxide occurs to give enone.

Steps of the process of Robinson Annulation

As in the question, we are given the end product of Robinson Annulation instead of reactants so that it will work backwardly. We will first be seeing how the end product is synthesised from aldol condensation and then Michael鈥檚 reaction.

In Robinson, Annulation dehydration occurs at last, but here hydration is done.

Hydration of product

In Robinson Annulation from cyclic aldol, a six-membered ring forms but here opposite occurs.

Cyclic aldol formation

Here Michael鈥檚 reaction is performed in the opposite direction.

Reverse Michael reaction

All steps together are:

Robinson Annulation Retrosynthesis