Chapter 22: Q5Pc (page 1155)
Predict the major products of the following reactions.
c)

Short Answer
c)

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Chapter 22: Q5Pc (page 1155)
Predict the major products of the following reactions.
c)

c)

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In Solved Problem 22-9, the target molecule was synthesized using a Michael addition to form the bond that is to the upper carbonyl group. Another approach is to use a Michael addition to form the bond that isto the other (lower) carbonyl group. Show how you would accomplish this alternative synthesis.
Show how the following ketones might be synthesized by using the acetoacetic ester synthesis.



Propose a mechanism for the acid-catalyzed reaction of cyclohexanone with pyrrolidine.
Question: Predict the products of the following reactions
a. Cyclopentanone +Br2 in acetic acid
The Knoevenagel condensation is a special case of the aldol condensation in which an active methylene compound reacts with an aldehyde or ketone, in the presence of a secondary amine as a basic catalyst, to produce a new C=C. Show the starting materials that made each of these by a Knoevenagel condensation.

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