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Hemoglobin (Hb) transports oxygen in the blood:

HbH+(aq) +O2(aq) +H2O(l)nHbO2(aq) +H3O+(aq)

In blood,H3O+is held nearly constant at4脳10- 8M.

(a) How does the equilibrium position change in the lungs?

(b) How does it change in O2-de铿乧ient cells?

(c) Excessive vomiting may lead to metabolic alkalosis, in which [H3O+] in blood decreases. How does this condition affect the ability of Hb to transportO2?

(d) Diabetes mellitus may lead to metabolic acidosis, in which [H3O+] in blood increases. How does this condition affect the ability of Hb to transportO2?

Short Answer

Expert verified

a) The reaction will shift to the right

b) The reaction will shift to the left

c) During alkalosis, it is easier for Hb to transport oxygen

d) During acidosis, it is more difficult for Hb to transport oxygen.

Step by step solution

01

To find how does the equilibrium position change in the lungs

HbH++O2+H2OHbO2+H3O+

02

To find How does it change in O2-de铿乧ient cells

(b) inO2- deficient cells

With deficient supply of oxygen in the reactant side, the reaction will shift to the left. This is according to Le Chatelier's principle. The lack of oxygen in the reactant disturbs the equilibrium and will produce adequate amount of oxygen to maintain a new equilibrium.

Hence the reaction will shift to the left

03

During alkalosis

(c)

During alkalosis, theH3O+ in blood decreases. With deficient[H3O+] in the product, the reaction will shift to the right As the[H3O+] increase during the shift in reaction, theHbO2 also increases. The oxygen binds to the haemoglobin and will be ready for transport.

Therefore during alkalosis, it is easier for Hb to transport oxygen

04

During acidosis

(d)

During acidosis, theH3O+ in blood increases. With abundant[H3O+] in the product, the reaction will shift to the left. As the[H3O+] is being consumed during the shift in reaction to produce the left side products,HbO2 also increases. The oxygen that binds to the hemoglobin for transport will decrease.

Therefore during acidosis, it is more difficult for Hb to transport oxygen.

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