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Chapter 17: Q. 17.60 (page 604)

How does a point mutation for an enzyme affect the order of amino acids in that protein?

Short Answer

Expert verified

The protein loses biological activity if the mutation changes an amino acid .

Step by step solution

01

Given Information

We need to explain how a point mutation for an enzyme affect the order of amino acids in that protein.

02

Explanation

The protein loses biological activity if the mutation changes an amino acid that is important for protein structure or function. If the protein is an enzyme, it may lose its ability to bind to its substrate or to react with it at the active site. When a changed enzyme can't catalyze a process, certain compounds can build up in the cell until they become poisonous, or essential substances can't be created. A mutation that arises in a major metabolic pathway or is involved in the construction of a cell membrane can be fatal. A genetic illness is defined as a protein deficit that is inherited.

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Most popular questions from this chapter

a. A point mutation changes a codon in the mRNA for an enzyme from GCC to GCA. Why is there no change in the amino acid order in the protein?

b. In sickle-cell anemia, a point mutation in the mRNA for hemoglobin results in the replacement of glutamate with valine in the resulting hemoglobin molecule. Why does the replacement of one amino acid cause such a drastic change in biological function?

Use three-letter and one-letter abbreviations to write the amino acid sequence for the peptide from each of the following mRNA sequences:

a. AAACCCUUGGCC

b. CCUCGCAGCGGCUGA

c. AUGCACAAGGAAGUACUG

What is a codon?

Match the following ATP yields to reactions a to g

1.5 ATP 2.5 ATP 7 ATP 50 ATP 12 ATP 32 ATP 36 ATP

a. Glucose forms two pyruvate

b. Pyruvate from acetyl CoA

c. Glucose from two acetyl CoA

d. Acetyl CoA goes to one turn of the citric acid cycle

e. Caproic acid is completely oxidized.

f. NADH + H+ is oxidized to NAD+

g. FADH2 is oxidized to FAD.

Identify each of the following as a nucleoside of a nucleotide:

a. deoxythymidine

b. guanosine

c. deoxyadenosine monophosphate

d. uridine monophosphate
See all solutions

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