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Problem 1

Which of the following produced symptoms of Parkinson’s disease in the early 1980s? a MOA b DMA c PNS d NMDA e MPTP.

Problem 2

Which of the following was/were responsible for demonstrating the chemical nature of neurotransmission? a Rene Descarte b Henry Dale c Claude Bernard d Otto Loewi e b and d.

Problem 3

Which of the following is the primary excitatory neurotransmitter in the brain? a epinephrine b chloride ion c acetylcholine d dopamine e glutamate.

Problem 4

Which of the following is responsible for inhibitory modulation of neurotransmission in the brain? a norepinephrine b acetylcholine c gamma-aminobutyric acid (GABA) d dopamine e none of the above.

Problem 5

The \(\mathrm{GABA}_{\mathrm{A}}\) receptor complex has recognition sites for which of the following? a barbiturates b steroids c alcohol d benzodiazepines e all of the above.

Problem 5

The GABAA receptor complex has recognition sites for which of the following? a barbiturates b steroids c alcohol d benzodiazepines e all of the above.

Problem 6

Cocaine’s principal mechanism of action in the CNS involves which of the following? a increased release of epinephrine b inhibition of monoamine oxidase c increased release of serotonin d blockade of dopamine reuptake e none of the above.

Problem 7

Which of the following is credited with the discovery of the anesthetic action of nitrous oxide in 1845? a Joseph Priestley b William Morton c Horace Wells d Otto Loewi e Henry Dale.

Problem 8

Which of the following receptors is presently the leading candidate to interact with gaseous anesthetics? a epinephrine (beta1) b acetylcholine (muscarinic) c glycine d GABAA e serotonin.

Problem 9

Botulinum toxin acts in the CNS by which of the following? a preventing the reuptake of acetylcholine b preventing the reuptake of serotonin c preventing the release of epinephrine d preventing the release of acetylcholine e none of the above.

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