Problem 3 Write a double-stranded DNA sequ... [FREE SOLUTION]

Chapter 21: Problem 3

Write a double-stranded DNA sequence that is 20 base pairs in length and is palindromic.

Short Answer

Expert verified

The 20 base pair double-stranded palindromic DNA sequence is 5' - ATATAGCGCT - 3' paired with 5' - AGCGCTATAT - 3'.

Step by step solution

Understand the base pairing

For DNA, the base pairings are Adenine (A) pairs with Thymine (T), and Guanine (G) pairs with Cytosine (C). Hence, if the sequence on one strand is A, the complementary strand will have T at that position, and vice versa. Similarly, if one strand has G, the complementary strand will have C at that position and vice versa.

Create a palindromic sequence

A palindromic DNA sequence means that the sequence reads the same way in 5' to 3' direction on both the strands. Therefore, the bases in first half of the sequence will be the reverse of those in the second half. Let's start with A-T base pairs for the first 5 and last 5 bases and G-C for the 5 bases in between, on the 5' to 3' strand: 5' - ATATAGCGCT - 3'

Create the complementary strand

According to the base pairing rules, the complementary strand will be 3' - TATATCGCGA - 5'. However, as DNA is antiparallel the same strand can be written in 5' to 3' direction as 5' - AGCGCTATAT - 3'.

Verify the palindromicity

So, the double-stranded DNA looks like this: 5' - ATATAGCGCT - 3' 3' - TATATCGCGA - 5'. Now if you read the sense strand from 5' to 3' and the antisense strand from 5' to 3', both should be the same, verifying the sequence is palindromic.

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91影视

Write a double-stranded DNA sequence that is 20 base pairs in length and is palindromic.

Short Answer

Step by step solution

Understand the base pairing

Create a palindromic sequence

Create the complementary strand

Verify the palindromicity

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