Chapter 10: Problem 24
What is an SMC complex? Describe two examples.
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Chapter 10: Problem 24
What is an SMC complex? Describe two examples.
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What are the roles of the core histone proteins and of histone \(\mathrm{H} 1\) in the compaction of eukaryotic DNA?
Beginning with the \(\mathrm{G}_{1}\) phase of the cell cycle, describe the level of compaction of the eukaryotic chromosome. How does the level of compaction change as the cell progresses through the cell cycle? Why is it necessary to further compact the chromatin during mitosis?
On rare occasions, a chromosome can suffer a small deletion that removes the centromere. When this occurs, the chromosome usually is not found within subsequent daughter cells. Explain why a chromosome without a centromere is not transmitted very efficiently from mother to daughter cells. (Note: If a chromosome is located outside the nucleus after telophase, it is degraded.)
What is a bacterial nucleoid? With regard to cellular membranes, what is the difference between a bacterial nucleoid and a eukaryotic nucleus?
Coumarins and quinolones are two classes of drugs that inhibit bacterial growth by directly inhibiting DNA gyrase. Discuss two reasons why inhibiting DNA gyrase also inhibits bacterial growth.
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