Q20P Question: Experiments in mice su... [FREE SOLUTION]

Chapter 6: Q20P (page 177)

Question: Experiments in mice suggest that pyro glutamylation (see Problem 19 ) increases the rate of aggregation of $amyloid - 尾$ protein. Propose an explanation for this observation.

Short Answer

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Pyro glutamylation promotes self-aggregation of pyro glutamylated $础尾$ and co-aggregation of non-modified $础尾$ .

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Concept Introduction

The free amino group of glutamic acid or glutamine cycles to form a lactam in pyroglutamic acid (PCA,5-oxyproline, pidolic acid), a naturally occurring derivative of amino acids.

Increase the rate of Aggregation of amyloid-β

Pyro glutamination of Glu drives misfolding of Ainto toxic aggregates and produces bulky hydrophobic nature to the N-terminus that might explain its enhanced aggregation properties.

Therefore, self-aggregation of pyro glutamylated A and co-aggregation of non-modified A is the result obtained.

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91影视

Question: Experiments in mice suggest that pyro glutamylation (see Problem 19 ) increases the rate of aggregation of $amyloid - 尾$ protein. Propose an explanation for this observation.

Short Answer

Step by step solution

Concept Introduction

Increase the rate of Aggregation of amyloid-β

One App. One Place for Learning.

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91影视

Question: Experiments in mice suggest that pyro glutamylation (see Problem 19 ) increases the rate of aggregation of amyloid-尾protein. Propose an explanation for this observation.

Short Answer

Step by step solution

Concept Introduction

Increase the rate of Aggregation of amyloid-β

One App. One Place for Learning.

Most popular questions from this chapter

Recommended explanations on Biology Textbooks

Biological Molecules

Ecological Levels

Chemistry of Life

Ecology

Biological Organisms

Substance Exchange

Study anywhere. Anytime. Across all devices.

Question: Experiments in mice suggest that pyro glutamylation (see Problem 19 ) increases the rate of aggregation of $amyloid - 尾$ protein. Propose an explanation for this observation.