Chapter 10: Q9P (page 319)
The diameter of the KcsA channel is . Why can't (diameter ) pass through this channel?
Short Answer
The ion within the channel restricts the entry of water molecule by hydrogen bond creation.
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Chapter 10: Q9P (page 319)
The diameter of the KcsA channel is . Why can't (diameter ) pass through this channel?
The ion within the channel restricts the entry of water molecule by hydrogen bond creation.
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Calculate the free energy required to move 1 mol of ions from the outside of the cell (where ) to the inside (where ) when the membrane potential is and the temperature is .
Why would overexpression of an MDR transporter in a cancer cell make cancer more difficult to treat?
The compound shown below is the antiparasitic drug miltefosine

(a) Is this compound a glycerophospholipid?
(b) How does miltefosine likely cross the parasite cell membrane?
(c) In what part(s) of the cell would the drug tend to accumulate? Explain.
(d) Miltefosine binds to a protein that also binds some sphingolipids and some glycerophospholipids. What feature common to all these compounds is recognized by the protein? The protein does not bind triacylglycerols.
Kidney cells contain a channel that allows intracellular ammonia to exit the cells. (a) Why did researchers originally believe that cells had no need for such a channel? (b) What is the free energy source for ammonia transport via the channel? (c) The same kidney cells also contain a proton pump that expels H+ from the cells. What is the free energy source for this pump, and how does its action prevent ammonia from moving back into the kidney cells?
Endothelial cells and pericytes in the retina of the eye have different mechanisms for glucose uptake. The figure shows the rate of glucose uptake for each type of cell in the presence of increasing amounts of sodium. What do these results reveal about the glucose transporter in each cell type?

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