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Chapter 22: Q25P (page 800)

High concentrations of 3-phosphoglycerate inhibit 6-phosphogluconate dehydrogenase. How does this regulatory mechanism help control the growth of a cancer cell?

Short Answer

Expert verified

The growth of cancer cells can be controlled by high concentrations of 3 -phosphoglycerate because it inhibits 6-phosphogluconate dehydrogenase, which in turn leads to a decrease in cell growth due to a lack of required biomolecules.

Step by step solution

01

Concept introduction

The 6-phosphogluconate dehydrogenase is the enzyme that plays a regulatory role in the pentose phosphate pathway.It catalyzes the reduction of 6 -phosphogluconate to form ribulose 5 -phosphate.

02

Working principle

Ribulose-5-phosphate later can be converted to ribose-5-phosphate.

Ribose-5-phosphate is the precursor of many biomolecules, such as amino acids and purines, and pyrimidines, which are used in DNA and RNA synthesis.

03

Conclusion

Thus, inactivation of 6-phosphogluconate dehydrogenase blocks the pentose phosphate pathway.

This decreases the production of a ribose-5-phosphate, a precursor of molecules required for cell growth.

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