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Chapter 16: QCS (page 557)

Carrier-Mediated Uptake of Lactate in Rat Hepatocytes.

Short Answer

Expert verified

It was seen that the rate of uptake and the distribution ratio between intra- and extracellular compartments of L- and D-lactate were studied in hepatocyte preparations from fed rats.

Also, the uptake of both L- and D-lactate apparently depended on both passive diffusion and carrier-mediated components

Step by step solution

01

Lactate Transport

It was studied that the lactate transport was inhibited by various anions; pyruvate was the most potent anion, whereas only high concentrations of ketone bodies were effective.

02

At low pH

At a low level of pH, L-lactate was concentrated in hepatocytes, but its affinity for the carrier appeared unchanged, suggesting the existence of a process gaining energy from the pH gradient across the cell membrane.

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