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Chapter 16: Q8CP (page 536)

Describe the role of glycogenin.

Short Answer

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Answer:

Glycogenin helps in the synthesis of glycogen. The glycogen chain is to be extended from a primer built by the protein glycogenin.

Step by step solution

01

Definition of Glycogenin

Glycogenin is known to be a homodimer of 37-kDa subunits. This enzyme is classified as a glycosyltransferase

02

Glycogenin reaction

Glycogeninacts is a glycosyltransferase which attaches a glucose residue to the OH group of its Tyr 194. This enzyme later helps extend the glucose chain by up to seven additional residues, which will help form a glycogen primer. The glucose residues are donated by UDPG (uridinedisphophoglucose).

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Glycogen Phosphorylase Structure and Activity

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Question: Glucose binds to glycogen phosphorylase and competitively inhibits the enzyme. What is the physiological advantage of this?
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