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Chapter 17: Q4P (page 586)

Explain why metabolic acidosis (Box 2-2) may result from the accumulation of some citric acid cycle intermediates.

Short Answer

Expert verified

These substances are acids that, if collected, can cause acidosis.

Step by step solution

01

About Acidosis

  • Acidosis occurs when the pHof the blood falls below the normal value ( pH of blood 7.4
  • The pH of substances that are a potential source of hydrogen tends to decrease.
02

Define why metabolic acidosis results accumulation of some citric acid cycle intermediates.

  • Blood functions as a buffer, allowing the pH value to be maintained.
  • However, a disruption in its blood buffer system can cause a drop in pH, which is referred to as acidosis.
  • In severe circumstances, acidosis can be lethal. For metabolism, the citric acid cycle is critical.
  • It produces a number of hydrogen-ion-producing intermediates such as citric acid, a-ketoglutaric acid, succinic acid, fumaric acid, malic acid, and oxalic acid.
  • These substances are acids that, if collected, can cause acidosis.

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Most popular questions from this chapter

(a) Explain why obligate anaerobes contain some citric acid cycle enzymes. (b) Why don鈥檛 these organisms have a complete citric acid cycle?

Which citric acid cycle intermediates can be directly used in gluconeogenesis? Which can be used for fatty acid synthesis? Which can be directly converted to amino acids?

What citric acid cycle intermediates would accumulate in the presence of malonate?

Malate generated inside the mitochondrion is translocated to the cytosol, where it is a substrate for cytosolic malic enzyme, which catalyzes the following reaction:

Explain how the activity of malic enzyme, which appears to catalyze a catabolic process, can promote biosynthetic reactions in the cytosol.

Malonate competes with succinate in the succinate dehydrogenase reaction. Explain why increasing the oxaloacetate concentration can overcome malonate inhibition.
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