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Chapter 17: Q16P (page 586)

What is the ratio of [isocitrate] to [citrate] under cellular conditions at 37掳C?

Short Answer

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Answer

The ratio of isocitrate to citrate at cellular level at the given temperature is found to be 0.14.

Step by step solution

01

Conversion of citrate to isocitrate

Aconitase is an enzyme that catalyzes the citrate to isocitrate conversion.

The reaction can be summarized as shown below:

The standard free energy change for aconitase obtained from the table of citric acid cycle reactions is found to be 螖Go'=5kJ mol-1.

02

Ratio of fumarate to succinate calculation

The ratio of isocitrate to citrate is calculated using the following equation:

螖G=螖G0+RTlnK

Substituting the values in the equation,

鈥�鈥�鈥�鈥�鈥�鈥�鈥�鈥�0=5000Jmol-1+8.314JK-1mol-1脳310K脳lnc(isocitrate)c(citrate)鈥�鈥�鈥�鈥�鈥�-lnc(isocitrate)c(citrate)=5000J/mol2577.34J/mol

Taking ln to the right-hand side,

c(isocitrate)c(citrate)=e-1.94=0.14

The ratio of isocitrate to citrate is 0.14.

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Most popular questions from this chapter

TheCO2produced in one round of the citric acid cycle does not originate in the acetyl carbons that entered that round. If acetyl-CoA is labeled withC14at its carbonyl carbon, how many rounds of the cycle are required beforeCO214is released?

Describe the five reactions of the pyruvate dehydrogenase multienzyme complex.

Malonate competes with succinate in the succinate dehydrogenase reaction. Explain why increasing the oxaloacetate concentration can overcome malonate inhibition.

Refer to Table 14-4 to explain why FAD rather than NAD+ is used

in the succinate dehydrogenase reaction.

Which steps of the citric acid cycle regulate flux through the cycle?
See all solutions

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