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Chapter 17: Q16P (page 586)

What is the ratio of [isocitrate] to [citrate] under cellular conditions at 37掳C?

Short Answer

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Answer

The ratio of isocitrate to citrate at cellular level at the given temperature is found to be 0.14.

Step by step solution

01

Conversion of citrate to isocitrate

Aconitase is an enzyme that catalyzes the citrate to isocitrate conversion.

The reaction can be summarized as shown below:

The standard free energy change for aconitase obtained from the table of citric acid cycle reactions is found to be 螖Go'=5kJ mol-1.

02

Ratio of fumarate to succinate calculation

The ratio of isocitrate to citrate is calculated using the following equation:

螖G=螖G0+RTlnK

Substituting the values in the equation,

鈥�鈥�鈥�鈥�鈥�鈥�鈥�鈥�0=5000Jmol-1+8.314JK-1mol-1脳310K脳lnc(isocitrate)c(citrate)鈥�鈥�鈥�鈥�鈥�-lnc(isocitrate)c(citrate)=5000J/mol2577.34J/mol

Taking ln to the right-hand side,

c(isocitrate)c(citrate)=e-1.94=0.14

The ratio of isocitrate to citrate is 0.14.

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Most popular questions from this chapter

The compound you identified in Problem 9 resembles glutamate and might therefore competitively inhibit glutamate transamination. How would this affect citric acid cycle activity?

Which steps of the citric acid cycle regulate flux through the cycle?

What is the 螖G掳鈥� value for the portion of the citric acid cycle that converts malate and acetyl-CoA to citrate?

Which one of the five steps of the pyruvate dehydrogenase complex reaction is most likely to be metabolically irreversible? Explain.

(a) Explain why obligate anaerobes contain some citric acid cycle enzymes. (b) Why don鈥檛 these organisms have a complete citric acid cycle?
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