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A protein that fails to fold properly in the endoplasmic reticulum may undergo O-mannosylation. Draw the structure of the resulting modified amino acid residue.

Short Answer

Expert verified

A protein linked with sugar moiety by the amino acid serine or threonine. O-linked oligosaccharides are linked to serine or threonine.

Step by step solution

01

Failing protein fold in the endoplasmic reticulum  

Oligomerization occuring in the endoplasmic reticulum, by N-linked glycosylation, and signal peptide cleavage has to occur earlier. If it doesn’t happen then it leads to the misfolding of the protein.

02

O-mannosylation formation

O-mannosylation will attach mannose to the protein by using the OH group of serine or threonine.

Mannose is linked with either serine or threonine.

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