Chapter 4: Q27. (page 96)
Draw the four stereoisomers of threonine as Fischer projections.
Short Answer

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Chapter 4: Q27. (page 96)
Draw the four stereoisomers of threonine as Fischer projections.

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The protein insulin consists of two polypeptides termed the A and B chains. Insulins from different organisms have been isolated and sequenced. Human and duck insulins have the same amino acid sequence with the exception of six amino acid residues, as shown below. Is the pI of human insulin lower than or higher than that of duck insulin?

Why do the values of ionizable groups differ between free amino acids and amino acid residues in polypeptides?
Some amino acids are synthesized by replacing the keto group(C=O) of an organic acid known as an α-keto acid with an amino group(C-NH+3). Identify the amino acids that can be produced this way from the following α-keto acids:

A sample of the amino acid tyrosine is barely soluble in water. Would a polypeptide containing only Tyr residues, poly(Tyr), be more or less soluble, assuming the total number of Tyr groups remains constant?
Draw the peptide ATLDAK. (a) Calculate its approximate pI. (b) What is its net charge at pH 7.0?
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