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Chapter 7: Problem 8

What three essential criteria must be met in order to execute a successful mapping cross?

Short Answer

Expert verified
Answer: The three essential criteria for a successful mapping cross are linkage, recombination, and large sample size.

Step by step solution

01

1. Linkage

The genes involved in the mapping cross should be linked, meaning they are located on the same chromosome or closely positioned together. This is crucial for determining genetic distances between those genes and observing the effects of recombination.
02

2. Recombination

The purpose of the mapping cross is to observe the frequency of recombination among offspring, which reflects the relative distances between the genes. To achieve this, the mapping cross must be set up in such a way that genetic material is exchanged between homologous chromosomes during meiosis, leading to the production of recombinant gametes. Parents involved in the cross should have different alleles for the genes being studied, allowing for clear observation of recombination events in the offspring.
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3. Large Sample Size

In order to obtain accurate and reliable results, a large number of offspring must be produced and analyzed for their gene combinations. A larger sample size minimizes the effects of random chance and provides a more accurate representation of recombination frequencies and genetic distances. It also ensures that rare recombination events are adequately represented in the results.

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Most popular questions from this chapter

Why are double-crossover events expected less frequently than single-crossover events?

Describe the cytological observation that suggests that crossing over occurs during the first meiotic prophase.

A female of genotype \\[ \frac{a}{+++} \\] produces 100 meiotic tetrads. Of these, 68 show no crossover events. Of the remaining 32,20 show a crossover between \(a\) and \(b\), 10 show a crossover between \(b\) and \(c,\) and 2 show a double crossover between \(a\) and \(b\) and between \(b\) and \(c .\) Of the 400 gametes produced, how many of each of the eight different genotypes will be produced? Assuming the order \(a-b-c\) and the allele arrangement shown above, what is the map distance between these loci?

Review the Chapter Concepts list on p. \(121 .\) Most of these center on the process of crossing over between linked genes. Write a short essay that discusses how crossing over can be detected and how the resultant data provide the basis of chromosome mapping.

In Drosophila, Dichaete ( \(D\) ) is a mutation on chromosome III with a dominant effect on wing shape. It is lethal when homozygous. The genes \(e\)bony body \((e)\) and pink eye (p) are recessive mutations on chromosome III. Flies from a Dichaete stock were crossed to homozygous ebony, pink flies, and the \(\mathrm{F}_{1}\) progeny with a Dichaete phenotype were backcrossed to the ebony, pink homozygotes. (a) Using the results of this backcross shown in the following table, diagram the cross, showing the genotypes of the parents and offspring of both crosses. (b) What is the sequence and interlocus distance between these three genes?
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