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Amino acids are the basic building block of the protein encoded in the DNA. These amino acids are produced out of genetic code that corresponds to a particular amino acid.

There exists physicochemical affinity between the amino acids’ codon and nucleotide triplets. The physical property is an essential reason for the repetitions of the amino acid codon that codes for a particular amino acid.

According to this theory, the amino acid biosynthesis pathway is responsible for the amino acids codon arrangement. The gene is another controlling factor that can determine the similar codon responsible for coding particular amino acids.

The genetic code can minimize transcriptional as well as translational error. It reduces the randomization of amino acids. After minimization of randomization, the genetic code transfers into amino acids.

According to this theory, the similarity between amino acid codons results from a reduction in randomization.

Hence, the codons corresponding to amino acids arise out of three major evolutionary theories: stereochemical, coevolution, and error minimization.