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Chapter 37: Q8. (page 1078)

What effect will a cAMP inhibitor have on a peptide
hormone-mediated signaling pathway?
a. It will prevent the hormone from binding to its
receptor.
b. It will prevent activation of a G-protein.
c. It will prevent activation of adenylate cyclase.
d. It will prevent activation of protein kinases.


Short Answer

Expert verified

The hormone won't be able to bind to the receptor because of it.

Hence, A is the correct option.

Step by step solution

01

Step 1. Introduction

Cyclic AMP binds to the regulatory subunits present during activation and that results in the release of catalytic subunit.

02

Step 2. Explanation of the correct option

G proteins act like molecular switches that are turned on by the GTP for GDP exchange on the G protein alpha subunit, which is then catalyzed by receptors.
When a ligand binds itself to the receptor and catalyzes the exchange of guanosine diphosphate (GDP) for GTP at the subunit, G protein-coupled receptors then become activated.

03

Step 3. Explanation of the incorrect options 

The secondary messenger here is cAMP. It gets in the cell membrane and initiates a number of enzymatic processes that further result in biochemical changes.

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