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What is the main prerequisite for clearance at the G2 checkpoint?

a. cell has reached a sufficient size

b. an adequate stockpile of nucleotides

c. accurate and complete DNA replication

d. proper attachment of mitotic spindle fibres to kinetochores

Short Answer

Expert verified

The main prerequisite for clearance at the G2 checkpoint is accurate and complete DNA replication. The correct option is (c).

Step by step solution

01

Step 1. Introduction

If specific criteria are not satisfied, the G2 checkpoint prevents entrance into mitosis.

02

Step 2. Explanation for Correct Answer

To guarantee that all chromosomes have been duplicated and the replicated DNA is undamaged, the G2 checkpoint is the most critical. Cell cycle halts when checkpoint systems identify issues with the DNA. The cell then seeks to either complete or replace or repair damaged DNA.

Thus, the correct option is - (c).

03

Step 3. Explanation for Incorrect Answers

The cell has reached a sufficient size which is monitored by the G1 phase, not G2. So, this is not the main prerequisite for clearance at the G2 checkpoint.

Thus, option (a) is incorrect.

An adequate stockpile of nucleotides is not checked by G2. So, this is not the main prerequisite for clearance at the G2

checkpoint.

Thus, option (b) is incorrect.

Proper attachment of mitotic spindle fibres to kinetochores is not checked by G2, instead, it is checked by the M phase. So, this is not the main prerequisite for clearance at the G2

checkpoint.

Thus, option (d) is incorrect.

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Most popular questions from this chapter

Chromosomes are duplicated during what stage of the cell cycle?

a. G1 phase

b. S phase

c. prophase

d. prometaphase

Figure 10.14 Human papillomavirus can cause cervical cancer. The virus encodes E6, a protein that binds p53. Based on this fact and what you know about p53, what effect do you think E6 binding has on p53 activity? a. E6 activates p53 b. E6 inactivates p53 c. E6 mutates p53 d. E6 binding marks p53 for degradation

Which protein is a positive regulator that phosphorylates other proteins when activated?

a. p53

b. retinoblastoma protein (Rb)

c. cyclin

d. cyclin-dependent kinase (Cdk)

What cell-cycle events will be affected in a cell that produces mutated (non-functional) cohesin protein?

Figure 10.6 Which of the following is the correct order of events in mitosis?

a. Sister chromatids line up at the metaphase plate. The kinetochore becomes attached to the mitotic spindle. The nucleus reforms and the cell divides. Cohesin proteins break down and the sister chromatids separate.

b. The kinetochore becomes attached to the mitotic spindle. Cohesin proteins break down and the sister chromatids separate. Sister chromatids line up at the metaphase plate. The nucleus reforms and

the cell divides.

c. The kinetochore becomes attached to the cohesin

proteins. Sister chromatids line up at the metaphase plate. The kinetochore breaks down and the sister chromatids separate. The nucleus reforms and the cell divides.

d. The kinetochore becomes attached to the mitotic spindle. Sister chromatids line up at the metaphase plate. Cohesin proteins break down and the sister chromatids separate. The nucleus reforms and the

cell divides.

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