Chapter 13: Problem 2
What adaptive advantage do synapses provide in nervous systems (i.e., why isn't the nervous system just a mesh of cells cytoplasmically connected through gap junctions)?
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Chapter 13: Problem 2
What adaptive advantage do synapses provide in nervous systems (i.e., why isn't the nervous system just a mesh of cells cytoplasmically connected through gap junctions)?
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Discuss the functional differences between ionotropic and metabotropic receptors.
Do you think there is one cellular mechanism of learning and memory or several? Cite studies in Aplysia and in the mammalian hippocampus to support your answer.
In his book Ionic Channels of Excitable Membranes, Bertil Hille characterized the importance of calcium ions: "Calcium channels ... serve as the only link to transduce depolarization into all the nonelectrical activities controlled by excitation. Without \(\mathrm{Ca}^{2+}\) channels our nervous system would have no outputs." Discuss this statement with reference to synaptic function.
Why is it difficult to show vesicular release of neurotransmitter molecules by electron microscopy?
What are the criteria for identification of the neurotransmitter at a particular synapse? Which two criteria are sufficient to conclude that a candidate is the neurotransmitter?
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