Chapter 4: Problem 16
Let \(Y_{1}
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Chapter 4: Problem 16
Let \(Y_{1}
These are the key concepts you need to understand to accurately answer the question.
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Verzani (2014), page 323 , presented a data set concerning the effect that different dosages of the drug AZT have on patients with HIV. The responses we consider are the p24 antigen levels of HIV patients after their treatment with AZT. Of the \(20 \mathrm{HIV}\) patients in the study, 10 were randomly assign the dosage of \(300 \mathrm{mg}\) of AZT while the other 10 were assigned \(600 \mathrm{mg}\). The hypotheses of interest are \(H_{0}: \Delta=0\) versus \(H_{1}: \Delta \neq 0\) where \(\Delta=\mu_{600}-\mu_{300}\) and \(\mu_{600}\) and \(\mu_{300}\) are the true mean p24 antigen levels under dosages of \(600 \mathrm{mg}\) and \(300 \mathrm{mg}\) of AZT, respectively. The data are given below but are also available in the file aztdoses. rda. \begin{tabular}{|l|llllllllll|} \hline \(300 \mathrm{mg}\) & 284 & 279 & 289 & 292 & 287 & 295 & 285 & 279 & 306 & 298 \\ \hline \(600 \mathrm{mg}\) & 298 & 307 & 297 & 279 & 291 & 335 & 299 & 300 & 306 & 291 \\ \hline \end{tabular} (a) Obtain comparison boxplots of the data. Identify outliers by patient. Comment on the comparison plots. (b) Compute the two-sample \(t\) -test and obtain the \(p\) -value. Are the data significant at the \(5 \%\) level of significance? (c) Obtain a point estimate of \(\Delta\) and a \(95 \%\) confidence interval for it. (d) Conclude in terms of the problem.
It is proposed to fit the Poisson distribution to the following data:
\begin{tabular}{c|ccccc}
\(x\) & 0 & 1 & 2 & 3 & \(3
Discuss the problem of finding a confidence interval for the difference \(\mu_{1}-\mu_{2}\) between the two means of two normal distributions if the variances \(\sigma_{1}^{2}\) and \(\sigma_{2}^{2}\) are known but not necessarily equal.
Here are the weights of 26 professional baseball pitchers; [see page 76 of Hettmansperger and McKean (2011) for the complete data set]. The data are in \(\mathrm{R}\) file bb. rda. Suppose we assume that the weight of a professional baseball pitcher is normally distributed with mean \(\mu\) and variance \(\sigma^{2}\). \(\begin{array}{llllllllllllll}160 & 175 & 180 & 185 & 185 & 185 & 190 & 190 & 195 & 195 & 195 & 200 & 200 \\ 200 & 200 & 205 & 205 & 210 & 210 & 218 & 219 & 220 & 222 & 225 & 225 & 232\end{array}\) (a) Obtain a histogram of the data. Based on this plot, is a normal probability model credible? (b) Obtain the maximum likelihood estimates of \(\mu, \sigma^{2}, \sigma\), and \(\mu / \sigma .\) Locate your estimate of \(\mu\) on your plot in part (a). Then overlay the normal pdf with these estimates on your histogram in Part (a). (c) Using the binomial model, obtain the maximum likelihood estimate of the proportion \(p\) of professional baseball pitchers who weigh over 215 pounds. (d) Determine the mle of \(p\) assuming that the weight of a professional baseball player follows the normal probability model \(N\left(\mu, \sigma^{2}\right)\) with \(\mu\) and \(\sigma\) unknown.
It is known that a random variable \(X\) has a Poisson distribution with parameter \(\mu\). A sample of 200 observations from this distribution has a mean equal to \(3.4\). Construct an approximate \(90 \%\) confidence interval for \(\mu\).
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