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Estimates of the prevalence of Alzheimer's disease have recently been provided by Pfeffer et al. [8]. The estimates are given in Table \(3.5 .\) Suppose an unrelated 77 -year-old man, 76 -year-old woman, and 82-year-old woman are selected from a community.Suppose we know two of the three people have Alzheimer's disease. What is the conditional probability that they are both younger than 80 years of age?$$\begin{array}{lcc}\hline \text { Age group } & \text { Males } & \text { Females } \\\\\hline 65-69 & 1.6 & 0.0 \\\70-74 & 0.0 & 2.2 \\\75-79 & 4.9 & 2.3 \\\80-84 & 8.6 & 7.8 \\\85+ & 35.0 & 27.9 \\\\\hline\end{array}$$

Short Answer

Expert verified
The probability is approximately 16.7% that both individuals with Alzheimer's are younger than 80.

Step by step solution

01

Identify the Variables

We have a 77-year-old man, a 76-year-old woman, and an 82-year-old woman. We know that two of these three individuals have Alzheimer's disease.
02

Determine Relevant Probabilities from Table

From the table, we find that the prevalence for a 77-year-old man (75-79 age group) is 4.9%, for a 76-year-old woman (75-79 age group) is 2.3%, and for an 82-year-old woman (80-84 age group) is 7.8%.
03

Set Up the Probability Expression

We need to find the probability that both individuals with Alzheimer's are younger than 80. Therefore, the potential pairs are the 77-year-old man paired with the 76-year-old woman (since both are younger than 80). The 82-year-old woman cannot be paired with either of the others to meet the age condition.
04

Calculate the Desired Probability

The probability that both individuals are younger than 80, given that two have Alzheimer's, takes into consideration the probabilities from the table. Calculate the probability for each pair and normalize by considering all age conditions.Let A1 represent the probability that both the 77-year-old man and 76-year-old woman have Alzheimer's:\[ P(A_1) = (0.049) imes (0.023) = 0.001127 \]Now, find the probability that the two individuals with Alzheimer's are among the pairs younger than 80:\[ P(A_1 ext{ conditioned}) = \frac{0.001127}{0.001127 + (0.049 imes 0.078) + (0.023 imes 0.078)} \]
05

Simplify the Probability Calculation

The denominator is calculated by evaluating probabilities of other possible outcomes. Thus:\[ P( ext{Both younger than 80}) = \frac{0.001127}{0.001127 + 0.003822 + 0.001794} \]This simplifies to:\[ \frac{0.001127}{0.006743} \approx 0.167 \]
06

Interpret Result

The conditional probability that both individuals with Alzheimer's disease are younger than 80 is approximately 16.7%.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Alzheimer's Disease Prevalence
Alzheimer's disease is a progressive neurological disorder that affects millions of people worldwide. Understanding its prevalence across different age groups is crucial in public health planning and allocating resources to manage its impact. In the context of the exercise, prevalence refers to the proportion of individuals within a specific age group who are diagnosed with Alzheimer's disease.
Alzheimer's prevalence varies significantly by age. Typically, the older a person gets, the higher the likelihood of developing the disease. This trend is evident in the provided prevalence table, where both men and women show an increasing percentage of Alzheimer's as the age groups progress.
For instance, in the table, the prevalence for men aged 65-69 is 1.6%, but it jumps to 8.6% in the 80-84 age group. This stark increase in the percentages is more pronounced in individuals aged 85 and above, as seen with the drastic rise to 35.0% for men. Recognizing such patterns helps us grasp how age influences the likelihood of developing Alzheimer's disease.
Age Group Probabilities
Probabilities for different age groups offer insight into how likely an individual within a specific group is to have a certain characteristic—in this case, Alzheimer's disease. Age group probabilities are derived from epidemiological data that show varying risks based on age and gender.
In our exercise, these probabilities are key to solving the conditional probability problem. We look at individual ages—77-year-old man, 76-year-old woman, and 82-year-old woman—and apply the respective age group probabilities from the table to determine their likelihood of having Alzheimer's disease.
This data-driven approach allows a formulation of the problem in statistical terms, where probabilities are calculated based on age group information. The probabilities are used in conjunction with given conditions to derive further insights, such as determining the likelihood of specific age groups being affected by Alzheimer's.
Biostatistics Problem Solving
Biostatistics plays a crucial role in medical research and public health by using statistical methods to understand biological phenomena. The exercise presents a classic biostatistics problem, where conditional probability is used to derive meaningful conclusions from given data.
Solving such problems involves several systematic steps, starting from identifying variables and determining known probabilities. You extract relevant data from tables—like prevalence percentages for specific age and gender groups—and use it to set up mathematical expressions that model the problem at hand. In our case, the desired outcome is the probability that individuals younger than 80 both have Alzheimer's.
After setting up the problem, you use formulas to calculate probabilities and apply conditions to narrow down potential outcomes. The power of biostatistics is in its ability to simplify complex relationships through statistical reasoning. This leads to actionable insights, like deducing that in our scenario, there's a 16.7% chance the two Alzheimer's patients are under 80, highlighting how likelihoods can be understood and applied in real-world contexts.

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