/*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} Problem 33 Interpreting Power Chantix (vare... [FREE SOLUTION] | 91Ó°ÊÓ

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Interpreting Power Chantix (varenicline) tablets are used as an aid to help people stop smoking. In a clinical trial, 129 subjects were treated with Chantix twice a day for 12 weeks, and 16 subjects experienced abdominal pain (based on data from Pfizer, Inc.). If someone claims that more than \(8 \%\) of Chantix users experience abdominal pain, that claim is supported with a hypothesis test conducted with a \(0.05\) significance level. Using \(0.18\) as an alternative value of \(p\), the power of the test is \(0.96\). Interpret this value of the power of the test.

Short Answer

Expert verified
The power of 0.96 means there is a 96% chance of detecting that more than 8% of users experience pain if the true proportion is 18%.

Step by step solution

01

- Understanding Hypothesis Testing

The power of a test refers to the probability that the test will correctly reject a false null hypothesis. This means the test will identify an effect when there is one.
02

- Define the Hypotheses

Set up the null hypothesis (H_0) and the alternative hypothesis (H_a):H_0: p = 0.08H_a: p > 0.08where p is the true proportion of Chantix users experiencing abdominal pain.
03

- Analyze the Power

The power of a test (0.96 in this case) shows how likely it is to reject the null hypothesis if the alternative hypothesis is true. Specifically, it tells us that there is a 96% chance of detecting an effect (i.e., abdominal pain rate higher than 8%) if the actual proportion of users experiencing abdominal pain is 18%.
04

- Contextual Interpretation

Since the power is 0.96, it means that the hypothesis test is very effective in detecting that more than 8% of Chantix users experience abdominal pain when the actual proportion is 18%.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Hypothesis Testing
Hypothesis testing is a statistical method used to make inferences about a population parameter. We start with an initial assumption or claim about the population - this is known as the hypothesis. In scientific research, hypothesis testing serves as a tool to decide whether to accept or reject this initial claim. There are two main steps:
  • Formulating the null and alternative hypotheses.
  • Using a sample data to determine whether the null hypothesis should be rejected.
A well-conducted hypothesis test provides a systematic way to test predictions and make sound conclusions based on data.
Null Hypothesis
The null hypothesis, denoted as \( H_0 \), is a statement of no effect or no difference. It's the hypothesis that researchers typically try to disprove or nullify in hypothesis testing.
In our example, the null hypothesis is \( H_0: p = 0.08 \), which means that 8% of Chantix users experience abdominal pain. This represents the status quo or the common assumption that needs evidence to be challenged. The goal of the hypothesis test is to see if there is enough evidence to reject the null hypothesis in favor of the alternative hypothesis.
Alternative Hypothesis
The alternative hypothesis, denoted as \( H_a \) or \( H_1 \), is a statement that indicates the presence of a particular effect or difference. It's what researchers aim to support with evidence gathered from the sample data.
For the Chantix example, the alternative hypothesis is \( H_a: p > 0.08 \). This hypothesis asserts that more than 8% of Chantix users experience abdominal pain. If the sample data provides sufficient evidence, the null hypothesis will be rejected in favor of the alternative hypothesis.
  • The alternative hypothesis represents the change or effect the researchers are testing for.
  • It is directly opposed to the null hypothesis.
Significance Level
The significance level, denoted as \( \alpha \), is the probability of rejecting the null hypothesis when it is actually true. It's a threshold set by the researcher to decide how much risk they are willing to take of making a Type I error (false positive).
In our Chantix example, the significance level is set to \( 0.05 \). This means there is a 5% risk of concluding that more than 8% of users experience abdominal pain when, in fact, the actual proportion is 8% or less.
  • The choice of significance level impacts the decision-making process in hypothesis testing.
  • Common significance levels are 0.05, 0.01, and 0.10.
Statistical Power
Statistical power is the probability that a test will correctly reject a false null hypothesis. In simpler terms, it measures how likely the test is to detect an effect if there really is one.
For the case of Chantix, the power of the test is 0.96, meaning there is a 96% chance of detecting an abdominal pain rate higher than 8% if the actual rate is 18%.
  • High power is desirable because it means there is a lower probability of making a Type II error (false negative).
  • Factors influencing power include the sample size, significance level, and the true effect size.
To summarize, a high power value indicates that the hypothesis test is effective in detecting significant differences or effects when they truly exist.

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