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Marcus reported on a study that treated children who had sleep apnea. Sleep apnea interferes with breathing while the child is asleep. Read the excerpts from the abstract, and answer the questions that follow it. (Adenotonsillectomy is surgery to remove the tonsils and adenoids.) (Source: Marcus et al., A randomized trial of adenotonsillectomy for childhood sleep apnea, New England Journal of Medicine, vol. \(368: 2366-2376\), June 20,2013\()\) We randomly assigned 464 children, 5 to 9 years of age, with the obstructive sleep apnea syndrome to early adenotonsillectomy or a strategy of watchful waiting \(\ldots .\) There were significantly greater improvements in behavioral, quality-of-life, and polysomnographic [sleep study] findings and significantly greater reduction in symptoms in the early-adenotonsillectomy group than in the watchful-waiting group \(\ldots\) a. Was the study a controlled experiment or an observational study? Explain how you know. b. Assuming that the study was properly conducted, can we conclude that the early surgery caused the improvements? Explain.

Short Answer

Expert verified
a. The study was a controlled experiment since the researchers intervened by randomly assigning children to early adenotonsillectomy or a strategy of watchful waiting. b. Yes, assuming the study was properly conducted and all other factors held constant, we can conclude that early surgery was the cause of the improvements observed.

Step by step solution

01

Identifying the nature of the study

To decide whether the study is observational or controlled, the student must look for whether the researchers intervened or merely observed. As stated in the excerpt, the researchers randomly assigned children to either early adenotonsillectomy or watchful waiting. This intervention, in this case, signifies a controlled experiment.
02

Causation from the controlled experiment

The second question implies understanding causation and association in experiments. In a controlled experiment, the researchers manipulate one variable and observe the changes that this manipulation causes in another variable. Given that this study was a controlled experiment, we can infer that the early surgery (independent variable) caused the significant improvements in behavior, quality-of-life, and polysomnographic findings (dependent variables).

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Observational Study
An observational study is one in which researchers take great care to observe and gather data without altering existing conditions. Instead of the researcher intervening or manipulating variables, as is done in a controlled experiment, participants in observational studies are simply observed in their natural settings or under normal circumstances.

For example, if we were to study dietary habits and health outcomes, an observational study might involve tracking what a group of individuals eat over a period of time and noting any health changes. Because the researchers do not control the diet of participants, they can't definitively state that specific dietary choices cause the health outcomes; they can only suggest there may be an association.

It is crucial to differentiate between observational studies and controlled experiments because conclusions about causation can usually only be drawn from the latter. Observational studies are more about correlation, where two factors may occur together, but one does not necessarily cause the other.
Causation in Experiments
In the realm of scientific research, establishing causation is quintessential for understanding the effects of one variable on another. In a controlled experiment, researchers introduce a deliberate change in the independent variable and meticulously observe the effects this has on the dependent variable. This allows them to state with confidence whether there is a direct cause-and-effect relationship.

When Marcus et al. conducted their study on sleep apnea, they manipulated the independent variable (early adenotonsillectomy) to gauge its impact on various dependent variables like behavior and sleep patterns, which are measured through polysomnographic findings. Since the participants were randomly assigned to either undergo the surgery or continue with watchful waiting, the influence of extraneous variables was minimized. This element of randomization is key to drawing credible conclusions about causation, assuming other criteria of the scientific method, such as proper control groups and elimination of biases, are also met.

Meticulous design and execution of controlled experiments can thus illuminate the true causal relationships that observational studies can only hint at through correlations.
Polysomnographic Findings
Polysomnographic findings provide invaluable insights into an individual's sleep patterns and are critical when diagnosing sleep disorders such as sleep apnea, as in the study by Marcus et al. Polysomnography is a comprehensive sleep study that records a variety of body functions during sleep, including brain electrical activity (EEG), eye movements, muscle activity, heart rhythm, and breathing patterns.

In the context of the aforementioned study, polysomnographic findings would have included data on how often the child's sleep was interrupted by difficulties in breathing and the overall quality of the sleep experienced. Because the surgery aimed to relieve these symptoms, improvements in these findings after early adenotonsillectomy, compared to the watchful-waiting group, would suggest that the surgery was successful in treating the sleep apnea.

It's critical for students to understand that these findings are not just numbers on a page; they represent real-world alterations in a child's sleep health. Such improvements can have profound impacts not only on the direct symptoms of sleep apnea but also on the general well-being and quality of life of a child, extending into behavioral and cognitive domains.

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