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Denosumab and Osteoporosis. A clinical study was conducted to see whether an antibody called denosumab is effective in the treatment of osteoporosis in postmenopausal women, as reported in the article "Denosumab in Postmenopausal Women with Low Bone Mineral Density (New England Journal of Medicine, Vol. 354. No. 8, pp. 821-831) by M. McClung et al. Postmenopausal women with osteoporosis were randomly assigned into groups that received either a placebo a six-month regimen of Denosumab at doses of 14mg, 60mg,100mg, or 210mg. The following table provides summary statistics for the body-mass indexes (BMI) of the women in each treatment group.

At the 10%significance level, do the data provide sufficient evidence to conclude that a difference exists in mean BMI for women in the five different treatment groups? Note: For the degrees of freedom in this exercise:

Short Answer

Expert verified

The data does not provide significant evidence that there is a difference in mean BMI for women in the five categories.

Step by step solution

01

Given information

The given data is

02

Explanation

The level of significance is α=0.10

Let us do the test hypotheses

Null hypothesis

H0: There is no difference exist in mean BMI for women in the five different groups.

Alternative hypothesis

Ha: There is difference exist in mean BMI for women in the five different groups.

The mean of all observations is

x¯=46(25.9)+54(25.8)+47(27.5)+42(26)+47(25.9)46+54+47+42+47

=6186236

=26.2136

The treatment sum of the square is

SSTR=∑nix¯i-x¯2

=46(25.9-26.2136)2+54(25.8-26.2136)2+47(27.5-26.2136)2

+(42-1)(4.6)2+(47-1)(4.3)2

role="math" localid="1652203360710" =98.0766

The error sum of squares is

SSE=∑ni-1si2

=(46-1)(4.3)2+(54-1)(5.3)2+(47-1)(5.8)2

+(42-1)(4.6)2+(47-1)(4.3)2

=5586.36

Then, the total sum of squares is

SST=SSTR+SSE

=98.0766+5586.36

=5684.4366

The mean treatment of the sum of squares is

MSTR=SSTRk-1

=98.07665-1

=24.1834

Then, the mean error of the sum of squares is

MSE=SSEn-k

=5586.36236-5

=24.1834

The F-static is

F-static=MSTRMSE

=24.519224.1834

When α=0.10and the critical value is 1.97

F-static (1.01)<critical value (1.97)

As a result, the crucial value approach

At a 10%significant threshold, the null hypothesis is not rejected.

As a result, the results are not statistically significant at the 10%level.

As a result, the data does not provide significant evidence that there is a difference in mean BMI for women in the five categories.

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