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Chapter 1: Q3RE (page 1)

Sample Design Literacy In 鈥淐ardiovascular Effects of Intravenous Triiodothyronine in Patients Undergoing Coronary Artery Bypass Graft Surgery鈥� [Journal of the American Medical Association (JAMA), Vol. 275, No. 9], the authors explain that patients were assigned to one of three groups: (1) a group treated with triidothyronine, (2) a group treated with normal saline bolus and dopamine, and (3) a placebo group given normal saline. The authors summarize the sample design as 鈥渞andomized and double-blind.鈥� Describe the meaning of 鈥渞andomized鈥� and 鈥渄ouble-blind鈥� in the context of this study.

Short Answer

Expert verified

Randomized means that the patients were assigned one of the three groups without following any pattern.

Double-blind implies that neither the patients nor the conductor of the experiment is aware of the treatment assigned to each of the patients.

Step by step solution

01

Given information

The three groups in the study:

(1) A group treated with triidothyronine

(2) A group treated with normal saline bolus and dopamine

(3) A placebo group administered normal saline

02

Step 2:Meaning of randomization and double-blind

Randomization means assigning the participants to a certain number of groups following a random process.

Also, an experiment is said to be double-blind if the treatments allocated to the subjects are unknown to the participants as well as the person conducting the experiment.

03

In the context of the experiment

In the study, the subjects are the patients of the study, and there are three groups of treatments.

When the patients are randomly assigned one of the three treatments, the experiment is said to be randomized.

Also, when the patients, as well as the person conducting the experiment, are unaware of the treatments being provided to the patients, the experiment is said to be double-blinded.

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