/*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} Problem 52 In this section, several models ... [FREE SOLUTION] | 91Ó°ÊÓ

91Ó°ÊÓ

In this section, several models are presented and the solution of the associated differential equation is given. Later in the chapter, we present methods for solving these differential equations. The delivery of a drug (such as an antibiotic) through an intravenous line may be modeled by the differential equation \(m^{\prime}(t)+k m(t)=I,\) where \(m(t)\) is the mass of the drug in the blood at time \(t \geq 0, k\) is a constant that describes the rate at which the drug is absorbed, and \(I\) is the infusion rate. a. Show by substitution that if the initial mass of drug in the blood is zero \((m(0)=0),\) then the solution of the initial value problem is \(m(t)=\frac{I}{k}\left(1-e^{-k t}\right)\) b. Graph the solution for \(I=10 \mathrm{mg} / \mathrm{hr}\) and \(k=0.05 \mathrm{hr}^{-1}\) c. Evaluate \(\lim _{t \rightarrow \infty} m(t),\) the steady-state drug level, and verify the result using the graph in part (b).

Short Answer

Expert verified
Answer: The steady-state drug level is 200 mg.

Step by step solution

01

Verify given solution

Firstly, we are given a solution to the differential equation and initial value problem \(m(t) = \frac{I}{k}\left(1 - e^{-kt}\right)\) when \(m(0) = 0\). To verify this solution, we have to plug it into the given differential equation, and check if it satisfies the equation. The original differential equation is \(m^{\prime}(t) + k m(t) = I\). Now, we find the derivative of the given solution with respect to time, \(m^{\prime}(t)\). \(m^{\prime}(t) = \frac{d}{dt} \left(\frac{I}{k}\left(1 - e^{-kt}\right)\right) = \frac{I}{k} \frac{d}{dt} (1 - e^{-kt}) = \frac{I}{k} \cdot ke^{-kt}\) Now, we plug the given solution \(m(t)\) and its derivative \(m^{\prime}(t)\) into the differential equation: \(m^{\prime}(t) + k m(t) = \frac{I}{k} \cdot ke^{-kt} + k\left(\frac{I}{k}\left(1 - e^{-kt}\right)\right) = I \cdot e^{-kt} + I - Ik \cdot e^{-kt}\) As we can see, the terms \(I \cdot e^{-kt}\) and \(- Ik \cdot e^{-kt}\) cancel out, and we are left with just: \(I = I\) This means that the given solution \(m(t)\) is, in fact, correct. Now, we want to verify the initial condition \(m(0) = 0\): \(m(0) = \frac{I}{k}\left(1 - e^{-k(0)}\right) = \frac{I}{k}(1 - e^0) = \frac{I}{k}(1 - 1) = 0\) The initial condition is also satisfied.
02

Graph the solution

We are asked to graph the solution \(m(t)=\frac{I}{k}\left(1-e^{-kt}\right)\) with the given values \(I=10 \mathrm{mg}/\mathrm{hr}\) and \(k=0.05\,\mathrm{hr}^{-1}\). Replacing these values gives: \(m(t) = \frac{10}{0.05} \left(1 - e^{-0.05t}\right) = 200\left(1 - e^{-0.05t}\right)\) To graph the solution, plot the function \(m(t) = 200\left(1 - e^{-0.05t}\right)\) over a suitable range of time values (e.g. \(t=0\) to \(t=50\,\mathrm{hr}\)). You should see the graph starting from zero and increasing until it reaches a steady-state value (which we'll find in the next step).
03

Find the steady-state drug level

We are asked to find the steady-state drug level, which is the limit of the mass of the drug as time goes to infinity: \(\lim_{t \rightarrow \infty} m(t) = \lim_{t \rightarrow \infty} 200\left(1-e^{-0.05t}\right)\) As \(t \rightarrow \infty\), the exponent \(-0.05t \rightarrow -\infty\), so \(e^{-0.05t} \rightarrow 0\): \(\lim_{t \rightarrow \infty} 200\left(1 - e^{-0.05t}\right) = 200(1 - 0) = 200\,\mathrm{mg}\) This means the steady-state drug level is \(200\,\mathrm{mg}\). To verify this result using the graph from step 2, observe that the graph approaches a horizontal asymptote at \(m(t) = 200\,\mathrm{mg}\) as time goes to infinity.

Unlock Step-by-Step Solutions & Ace Your Exams!

  • Full Textbook Solutions

    Get detailed explanations and key concepts

  • Unlimited Al creation

    Al flashcards, explanations, exams and more...

  • Ads-free access

    To over 500 millions flashcards

  • Money-back guarantee

    We refund you if you fail your exam.

Over 30 million students worldwide already upgrade their learning with 91Ó°ÊÓ!

Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Initial Value Problem
An initial value problem in mathematics, particularly in differential equations, involves finding a function that satisfies a given differential equation and that also meets specific initial conditions. In pharmacokinetics and other applications, this allows modelers to predict how a system behaves over time, starting from an initial state.

For instance, when a drug is administrated intravenously, the initial value problem can describe how the concentration of the drug changes in the bloodstream over time. Given the differential equation m'(t) + k m(t) = I, where m(t) represents the mass of the drug at time t, and certain parameters are known (like the rate of absorption k and the infusion rate I), providing an initial condition (such as m(0) = 0 when no drug is initially present) allows us to predict the drug concentration at any subsequent time.

This kind of problem is a staple in mathematics because it can be applied to many real-world phenomena, where we know the rate of change of something and its initial state, and we want to find out how it evolves over time.
Steady-State Drug Level
The term steady-state drug level refers to the concentration of a medication in the bloodstream that does not change significantly over time, assuming a constant rate of drug administration and elimination. This is a crucial concept in pharmacology as it helps in determining the proper dosing regimen to achieve therapeutic drug concentrations without reaching toxic levels.

With respect to differential equations, the steady-state level corresponds to what happens when the net change over time balances out. Mathematically, we reach this value when the derivative of our concentration function, m'(t), approaches zero as time goes towards infinity. It's important for healthcare providers to understand this concept to ensure that patients receive the correct amount of a medication necessary to maintain therapeutic levels without overdosing.
Limit of a Function
In calculus, the limit of a function is a fundamental concept that describes the behavior of that function as it approaches a particular point or as the input (or

One App. One Place for Learning.

All the tools & learning materials you need for study success - in one app.

Get started for free

Most popular questions from this chapter

Find the equilibrium solution of the following equations, make a sketch of the direction field, for \(t \geq 0,\) and determine whether the equilibrium solution is stable. The direction field needs to indicate only whether solutions are increasing or decreasing on either side of the equilibrium solution. $$y^{\prime}(t)=-6 y+12$$

An endowment is an investment account in which the balance ideally remains constant and withdrawals are made on the interest earned by the account. Such an account may be modeled by the initial value problem \(B^{\prime}(t)=r B-m,\) for \(t \geq 0,\) with \(B(0)=B_{0} .\) The constant \(r>0\) reflects the annual interest rate, \(m>0\) is the annual rate of withdrawal, \(B_{0}\) is the initial balance in the account, and \(t\) is measured in years. a. Solve the initial value problem with \(r=0.05, m=\$ 1000 /\) year, and \(B_{0}=\$ 15,000 .\) Does the balance in the account increase or decrease? b. If \(r=0.05\) and \(B_{0}=\$ 50,000,\) what is the annual withdrawal rate \(m\) that ensures a constant balance in the account? What is the constant balance?

A physiological model A common assumption in modeling drug assimilation is that the blood volume in a person is a single compartment that behaves like a stirred tank. Suppose the blood volume is a four-liter tank that initially has a zero concentration of a particular drug. At time \(t=0,\) an intravenous line is inserted into a vein (into the tank) that carries a drug solution with a concentration of \(500 \mathrm{mg} / \mathrm{L} .\) The inflow rate is \(0.06 \mathrm{L} / \mathrm{min} .\) Assume the drug is quickly mixed thoroughly in the blood and that the volume of blood remains constant. a. Write an initial value problem that models the mass of the drug in the blood, for \(t \geq 0\) b. Solve the initial value problem, and graph both the mass of the drug and the concentration of the drug. c. What is the steady-state mass of the drug in the blood? d. After how many minutes does the drug mass reach \(90 \%\) of its steady-state level?

Direction field analysis Consider the first-order initial value problem \(y^{\prime}(t)=a y+b, y(0)=A,\) for \(t \geq 0,\) where \(a, b,\) and \(A\) are real numbers. a. Explain why \(y=-b / a\) is an equilibrium solution and corresponds to a horizontal line in the direction field. b. Draw a representative direction field in the case that \(a>0\) Show that if \(A>-b / a\), then the solution increases for \(t \geq 0,\) and that if \(A<-b / a,\) then the solution decreases for \(t \geq 0\). c. Draw a representative direction field in the case that \(a<0\) Show that if \(A>-b / a\), then the solution decreases for \(t \geq 0,\) and that if \(A<-b / a,\) then the solution increases for \(t \geq 0\).

The following initial value problems model the payoff of a loan. In each case, solve the initial value problem, for \(t \geq 0,\) graph the solution, and determine the first month in which the loan balance is zero. $$ B^{\prime}(t)=0.005 B-500, B(0)=50,000 $$

See all solutions

Recommended explanations on Math Textbooks

View all explanations

What do you think about this solution?

We value your feedback to improve our textbook solutions.

Study anywhere. Anytime. Across all devices.