Chapter 18: Problem 31
What does the expression essential amino acid mean?
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Chapter 18: Problem 31
What does the expression essential amino acid mean?
These are the key concepts you need to understand to accurately answer the question.
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Protein molecules are usually quite large and yet often water-soluble. They are soluble in water because they can fold themselves into spherical shapes in which the polar (hydrophilic) side chains are on the surface and the nonpolar (hydrophobic) side chains are buried inside the sphere. Of the amino acids Ala, Ser, Phe, lle, Arg, and Asp, (a) Which would you expect to find on the surface of a water-soluble protein? (b) Which would you expect to find buried deep inside the protein structure? (c) Which might be in either location depending on the solution pH?
What is a peptide linkage?
This polymer is called silicone and has a noncarbon, "inorganic" backbone of alternating silicon and oxygen atoms: (a) Put a set of parentheses around one monomer unit. (b) Another name for this polymer is polydimethylsiloxane. Explain why it has this name.
Amino acids are a sort of self-contradiction because they contain both a basic group (the \(\mathrm{NH}_{2}\) end) and an acidic group (the \(\mathrm{CO}_{2} \mathrm{H}\) end \()\) in the same molecule. Therefore, it should not surprise you that, when dissolved in water, an amino acid can react with itself to form what is known as a zwitterion. Based on this information, (a) Draw the structural formula for the form of the amino acid alanine you would expect to find in a neutral water solution. What is the net electrical charge on this species? (b) Enough concentrated \(\mathrm{HCl}\) is added to the solution of part (a) to make it strongly acidic. Draw the structural formula for the form of alanine you expect to find in this solution. What is the net charge on the alanine? (c) Enough concentrated \(\mathrm{NaOH}\) is added to the solution of part (a) to make it strongly basic. Draw the structural formula for the form of alanine you expect to find in this solution. What is the net charge on the alanine now?
In an amino acid, a carbon atom bound directly to the carbonyl carbon of the acid function is called the alpha carbon \((\alpha\) -carbon \() .\) Draw glycine, point out the \(\alpha\) -carbon, and then explain why all 20 amino acids used to build human proteins are called \(\alpha\) -amino acids. Then draw the simplest \(\beta\) -amino acid.
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