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Chapter 12: Problem 54

Several years ago a biomedical company produced and marketed a new, efficient heart valve implant. It was later withdrawn from the market, however, because patients using it suffered from severe loss of red blood cells. Describe what properties of the valve could have been responsible for this result.

Short Answer

Expert verified
In summary, the severe loss of red blood cells in patients using the heart valve implant could be attributed to factors like the valve's design, material, operation, and implantation procedure. Possibilities include sharp edges, ill-fitting design, turbulence, biocompatibility of materials, wear and tear, valve malfunction, and improper surgical techniques. Analyzing these factors could help determine the cause of this adverse outcome.

Step by step solution

01

Examine the design of the valve

The design of the heart valve implant could be responsible for the severe loss of red blood cells. It's important to consider if the valve had sharp edges or if it was not designed accurately to match the patient's anatomy. Sharp edges or ill-fitting designs might have contributed to the increase in hemolysis (the destruction of red blood cells). Consider if the valve caused excessive turbulence when the blood flowed through it, as this may have led to the red blood cells breaking.
02

Evaluate the materials used in the implant

The material of the heart valve implant might have contributed to the severe loss of red blood cells. Assess if the materials used were biocompatible and suitable for long-term implantation into the body. Materials that are not biocompatible could have caused inflammation or initiated the immune system to attack the valve leading to disruption of blood flow and subsequent hemolysis. Also, evaluate if the valve's material was prone to wear and tear, which could release particles into the bloodstream and damage red blood cells.
03

Consider the operation of the valve

The way the valve operated might have played a role in the loss of red blood cells. Examine if the valve opened and closed efficiently to maintain proper blood flow. Inadequate opening or closing of the valve could cause turbulence and sheer stress, which can damage the red blood cells. Also, investigate if the valve was prone to malfunctioning or if there were any manufacturing defects that could have led to improper functionality and subsequent complications.
04

Assess the implantation procedure

Though not solely based on the valve properties, the implantation procedure should also be considered. Examine if the surgical implantation technique was appropriate and if it could have led to complications that caused the valve to damage red blood cells. An improper surgical technique or placement of the valve can cause blood flow disturbance, leading to hemolysis. In conclusion, to understand why patients using the heart valve implant suffered from severe loss of red blood cells, we have to consider several factors related to the design, material, and operation of the valve, as well as the implantation procedure. By analyzing these factors, we can identify possible causes for this adverse outcome.

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