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Magazine Chapter 16: Q. 16.67 (page 581)
If glutamate were replaced by proline in a protein, how might the tertiary structure be affected?
Short Answer
Expert verified
The replacement of the protein glutamate with proline affects tertiary structure, the reasons are
- Within a protein, amino acids with non-polar groups gather far from the aqueous environment to form a hydrophobic center within the protein molecule.
Step by step solution
01
Introduction - Protein and the functions of tertiary structure
- Tertiary structure is the three-dimensional shape of a protein.
- Tertiary structure includes attractive and repulsive forces between the R groups of amino acids in the polypeptide chain of a protein.
02
Given Information - Glutamate Structure We need to find The effect on tertiary structure if the protein glutamate is replaced by proline.
- The structure of glutamic acid is:
- The amino acid is a polar acidic amino acid because of the presence of a polar group.
- This protein causes a hydrophilic interaction between the two polar amino acids.
- This is the gravitational pull between the external aqueous environment and the R group of polar amino acids.
- During this attraction, polar amino acids travel toward the outer surface of the protein, where they form hydrogen bonds with water.
03
Given Information - Proline StructureWe need to find The effect on tertiary structure if the protein glutamate is replaced by proline.
- The structure of Proline is:
04
Explanation The effect on tertiary structure if the protein glutamate is replaced by proline.
- The given Amino acids are characterized as non-polar amino acids.
- It is known that non-polar amino acids have hydrophobic interactions.
- This is the interaction between two non-polargroups.
- Within a protein, amino acids with non-polargroups gather far from the aqueous environment to form a hydrophobic center within the protein molecule.
- Therefore, for these reasons, tertiary structureis affected.
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