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A Drosopbila female homozygous for a recessive X-linked mutation that causes vermilion eyes is mated to a wild-type male with red eyes. Among their progeny, all the sons have vermilion eyes, and nearly all the daughters have red eyes; however, a few daughters have vermilion eyes. Explain the origin of these vermilion-eyed daughters.

Short Answer

Expert verified
Vermilion-eyed daughters result from non-disjunction causing double vermilion allele (XvXv) inheritance.

Step by step solution

01

Understanding the Genetic Makeup

The X-linked mutation for vermilion eyes is recessive. A homozygous female for this trait means she has two copies of the vermilion mutation on her X chromosomes (XvXv). The wild-type male has a normal X chromosome and a Y chromosome (XY).
02

Analyzing the Progeny of the Cross

The female can only pass on the vermilion mutation (Xv) to her offspring, since both her X chromosomes have this mutation. The male can pass either his X chromosome (with the wild-type allele) or his Y chromosome.
03

Determining Male Offspring Genotypes

All sons receive their X chromosome from the mother, which means all sons will have the genotype (XvY) and express the vermilion eye phenotype, as they have no second X chromosome to mask the recessive trait.
04

Determining Female Offspring Genotypes

All daughters receive an X chromosome from each parent, resulting in genotypes that could be either (XvX) - vermilion from the mother, wild-type from the father, leading to red eyes due to the dominant wild-type allele, or (XvXv) if non-disjunction has occurred.
05

Explaining the Anomalies with Vermilion-eyed Daughters

The presence of vermilion-eyed daughters indicates a genetic anomaly, most likely due to non-disjunction during meiosis, leading to a possible X chromosome arrangement like (XvXv), where both chromosomes carry the vermilion mutation, leading to vermilion eyes.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

X-linked Inheritance
X-linked inheritance refers to genes that are located on the X chromosome. Because females have two X chromosomes (XX), they can be carriers for a trait without expressing it if it's recessive, as one healthy dominant gene can mask the recessive trait.
Males, however, have only one X chromosome (XY), so if they inherit a recessive trait on their single X chromosome, they will express it because they do not have another X chromosome to mask the recessive trait—this is why you often see higher expression of X-linked traits in males.
For the Drosophila case mentioned, the vermilion eye color is a recessive X-linked mutation. A homozygous female (XvXv) can only pass the vermilion gene to her male offspring, who will then display vermilion eyes, while the dominant gene from the male wild-type results in red eyes for most female offspring.
Non-disjunction
Non-disjunction is an error in the distribution of chromosomes during meiosis. It results in gametes that have an abnormal number of chromosomes. During normal meiosis, homologous chromosomes or sister chromatids are evenly split, but non-disjunction leaves one gamete with an extra chromosome and another with a missing one.
In the context of the Drosophila exercise, the presence of vermilion-eyed daughters is a classic explanation of non-disjunction. In these cases, a (XvXv) gamete from the mother fuses with the (X) gamete from the father, leading to a daughter with two vermilion alleles, thus expressing the vermilion eye phenotype.
Genetic Mutation
Genetic mutation is a change that occurs in the DNA sequence, either due to errors during DNA replication or as a result of environmental factors. Mutations can be silent, missense, nonsense, or affect regulatory sequences.
A major type of mutation is the point mutation, where a single base pair is altered. For the vermilion-eyed trait in the Drosophila, the mutation on the X chromosome disrupts normal pigmentation, resulting in the vermilion eye color.
  • Recessive mutations often require two copies to express the trait, which is why male Drosophila display the vermilion eyes when having just one copy.
It’s important to note that genetic mutations can either be inherited or occur during an organism’s lifetime.
Recessive Traits
Recessive traits are traits that require two copies of the recessive allele to be expressed. If an individual has one dominant and one recessive allele for a trait, the dominant allele typically masks the recessive one and determines the phenotype.
In X-linked recessive traits, since males have only one X chromosome, they will express the trait if they inherit an X chromosome with the recessive allele. Females would need two copies of the recessive allele, one from each parent, to exhibit the trait.
  • These principles explain why the male Drosophila easily exhibit vermilion eyes, while females predominantly exhibit the full-color phenotype unless there is an anomaly like non-disjunction.
Understanding the dynamics of recessive traits helps explain how some genetic conditions are inherited and expressed across generations.

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