/*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} Problem 3 Disease with no immunity. Consid... [FREE SOLUTION] | 91Ó°ÊÓ

91Ó°ÊÓ

Disease with no immunity. Consider an infectious disease where all those infected become susceptible again upon recovering from the disease. Let \(S(t)\) and \(I(t)\) denote numbers of infectious and susceptibles and let \(\beta\) be the transmission coefficient and \(\gamma^{-1}\) the infectious period. Develop a model as two differential equations for \(S\) and \(I\).

Short Answer

Expert verified
The model is defined by: \(\frac{dS}{dt} = -\beta S(t) I(t) + \gamma I(t)\) and \(\frac{dI}{dt} = \beta S(t) I(t) - \gamma I(t)\).

Step by step solution

01

Define the Parameters and Variables

We are given two variables: \(S(t)\) for susceptibles and \(I(t)\) for infectious individuals. The parameters include \(\beta\), the transmission coefficient, representing the rate of contact that results in infection, and \(\gamma^{-1}\), representing the average duration that an individual remains infectious.
02

Understand Disease Dynamics Assumptions

This disease has no immunity post-recovery, meaning individuals who recover from the disease become susceptible again immediately. This suggests a cyclic nature between the susceptible and infectious populations.
03

Formulate the Susceptible Equation

The susceptible population changes by losing individuals to infection and gaining individuals from the recovery of the infectious. The rate of infection is \(\beta S(t) I(t)\). Hence, the equation for \(\frac{dS}{dt}\) is: \(\frac{dS}{dt} = -\beta S(t) I(t) + \gamma I(t)\).
04

Formulate the Infectious Equation

The infectious population increases by infection and decreases as individuals recover. Individuals become infectious at the rate \(\beta S(t) I(t)\) and recover at the rate \(\gamma I(t)\). So, the equation for \(\frac{dI}{dt}\) is: \(\frac{dI}{dt} = \beta S(t) I(t) - \gamma I(t)\).
05

Combine into a System of Differential Equations

From the formulated equations, the system is: \(\frac{dS}{dt} = -\beta S(t) I(t) + \gamma I(t)\) and \(\frac{dI}{dt} = \beta S(t) I(t) - \gamma I(t)\). These equations describe the dynamics of the disease where recovered individuals become susceptible again.

Unlock Step-by-Step Solutions & Ace Your Exams!

  • Full Textbook Solutions

    Get detailed explanations and key concepts

  • Unlimited Al creation

    Al flashcards, explanations, exams and more...

  • Ads-free access

    To over 500 millions flashcards

  • Money-back guarantee

    We refund you if you fail your exam.

Over 30 million students worldwide already upgrade their learning with 91Ó°ÊÓ!

Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Infectious Disease Modelling
Infectious disease modelling is a fascinating mathematical tool used to understand the spread and control of diseases within a population. By using mathematics, we can predict how diseases behave and evolve, which is crucial for planning interventions to prevent outbreaks. A key feature of these models is their ability to simulate scenarios where individuals transition between different states: susceptible, infectious, and recovered. In our scenario, this becomes even more interesting as recovered individuals return to being susceptible, creating a dynamic loop.

Models like these help us visualize and quantify interactions in a population. They can help public health officials decide the best ways to reduce the number of infections, such as by implementing vaccination or social distancing measures.
  • The interaction between susceptible and infectious groups impacts how quickly the disease spreads.
  • Adjusting parameters like the transmission coefficient, \( \beta \), can simulate interventions' effectiveness.
By simulating the disease dynamics, we gain insight into how different factors affect the spread of infectious diseases over time. This understanding aids significantly in crafting strategies to combat real-world outbreaks.
Differential Equations
Differential equations are fundamental in infectious disease modelling because they represent how a quantity changes over time. In the case of our infectious disease model, these changes describe the rates at which people become infected or recover.

A differential equation expresses the relationship between these rates and the number of individuals in each category at a given time. For example, the change in the number of susceptible individuals, \( \frac{dS}{dt} \), depends on the current number of both susceptible and infectious individuals.
  • The differential equation for susceptibles: \( \frac{dS}{dt} = -\beta S(t) I(t) + \gamma I(t) \).
  • The differential equation for infectives: \( \frac{dI}{dt} = \beta S(t) I(t) - \gamma I(t) \).
These equations form a system of equations, providing a dynamic picture of the disease over time. Solutions to these equations help predict how the disease will progress in different circumstances, making differential equations a powerful tool in epidemiology.
Epidemiology
Epidemiology is the study of how diseases affect populations. It involves studying disease patterns to develop strategies to reduce the burden of illnesses on society. By understanding how diseases spread, we can identify ways to intervene and mitigate their impact.

In our model, to understand epidemiology, we need to know that there is no lasting immunity. This means the disease behaves in a cyclic manner with individuals repeatedly moving between being susceptible and infectious. This repeated cycle is characteristic of many real-world infectious diseases like the common cold or some strains of influenza.
  • Epidemiologists use models to simulate how diseases spread under different conditions.
  • Such models help in exploring interventions and policies to prevent widespread outbreaks.
By integrating data from real-world occurrences, epidemiologists refine these models to better predict actual disease spread, making epidemiology an essential field for public health planning and response.

One App. One Place for Learning.

All the tools & learning materials you need for study success - in one app.

Get started for free

Most popular questions from this chapter

Wine fermentation. In the fermentation of wine, yeast cells digest sugar from the grapes and produce alcohol as a waste product, which is toxic to the yeast cells. Develop a model consisting of three coupled differential equations for the density of yeast cells, the amount of alcohol and the amount of sugar. In the model assume the yeast cells have a per-capita birth rate proportional to the amount of sugar, and a per-capita death rate proportional to the amount of alcohol present. Assume the rate of alcohol produced is proportional to the density of yeast cells, and the rate of sugar consumed is proportional to the density of yeast cells.

Spread of a religion. A new religion is spreading through a community in a remote country. The community is made up of unbelievers (with numbers denoted by \(U(t))\), converts (numbers \(C(t))\) and missionaries (numbers \(M(t)) .\) Assume only contacts between missionaries and unbelievers result in an unbeliever becoming a convert. A constant proportion of converted each year become ordained as missionaries. Formulate a system of differential equations for these populations. Your model should have the property that the total population remains constant over time. Births and deaths may be ignored and relapses to unconverted of either converts or missionaries may be neglected.

Diseases with carriers. Develop a model for an infectious disease where there is immunity for only some of those who recover; others 'recover' to become permanent carriers, who can still cause infections. Thus susceptibles, \(S(t)\), may be infected by either infectious individuals, \(I(t)\), or carriers, \(C(t) .\) A carrier can infect others at a reduced rate compared to infectious individuals but shows no symptoms. (a) Give a suitable compartment diagram for this model. (b) Assume there is a fixed proportion \(q\) of those recovering from the infection become carriers. Assume transmission rates \(\beta_{1}\) for normal infectives and \(\beta_{2}\) for carriers and assume that individuals remain infective for a mean time \(\gamma^{-1} .\) Give equations for the number of susceptibles, \(S(t)\), the number of infectious, \(I(t)\), the number of carriers, \(C(t)\) and the number of recovered who are immune, \(R(t)\). (c) Give at least one example of an infectious disease that could be modelled by the equation you have developed.

Symbiosis. Symbiosis is where two species interact with each other, in a mutually beneficial way. Starting with a compartmental diagram, formulate a differential equation model describing this process, based on the following. Assume the per-capita death rate for each species to be constant, but the per- capita birth rate to be proportional to the density of the other species. In other words, the presence of the other species is necessary for continued existence. (Define all parameters and variables of the model.)

I model, Contagious for life. Consider a disease where all those infected remain contagious for life. Ignore all births and deaths. (a) Write down suitable word equations for the rate of change of numbers of susceptibles and infectives. Hence develop a pair of differential equations. (Define any notation you introduce.) (b) With a transmission coefficient of 0.002, and initial numbers of susceptibles 500 and infectives 1, use Maple or MATLAB to sketch time- dependent plots for the sub-populations (susceptibles and infectives) over time.

See all solutions

Recommended explanations on Biology Textbooks

View all explanations

What do you think about this solution?

We value your feedback to improve our textbook solutions.

Study anywhere. Anytime. Across all devices.