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The sympathetic and parasympathetic systems are part of the autonomic nervous system (ANS), which controls involuntary bodily functions like heart rate, digestion, and respiration. The sympathetic system is responsible for the "fight or flight" response and increases alertness, while the parasympathetic system helps to relax and "rest and digest" by conserving energy.

In the sympathetic system, the ganglia are located close to the spinal cord in a structure called the sympathetic chain or sympathetic trunk. There are 22 pairs of ganglia, organized in a vertical line on both sides of the spinal cord. In the parasympathetic system, the ganglia are located near or within the organs they serve. This is a key difference between the two systems.

The sympathetic nerves originate from the thoracic and lumbar regions of the spinal cord (T1-L2) and extend to various target organs and tissues in the body. The sympathetic nerves form a network of interconnected neurons called the sympathetic plexus, which is responsible for many involuntary functions in the body. The parasympathetic nerves originate from the brainstem (cranial nerves) and the sacral region of the spinal cord (S2-S4). The cranial nerves include the oculomotor, facial, glossopharyngeal, and vagus nerves, which innervate various organs like the heart, lungs, and digestive system. The sacral nerves serve the pelvic region, including the bladder, colon, and rectum. In summary, the sympathetic system has its ganglia closer to the spinal cord and a more widespread distribution of nerves, while the parasympathetic system's ganglia are closer to the organs, and its nerves have a more specific distribution, focused on the cranial and sacral regions.