Chapter 6: Problem 16
Describe the unique features of ascomycetes that lend themselves to genetic analysis.
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Chapter 6: Problem 16
Describe the unique features of ascomycetes that lend themselves to genetic analysis.
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Researchers have discovered that some regions of chromosomes are much more likely than others to cross over. We might call such a region a "hot spot" for crossing over. Let's suppose that two genes, gene \(A\) and gene \(B\), are \(5,000,000 \mathrm{bp}\) apart on the same chromosome. Genes \(A\) and \(B\) are in a hot spot for crossing over. Two other genes, let's call them gene \(C\) and gene \(D\), are also \(5,000,000 \mathrm{bp}\) apart but are not in a hot spot for recombination. If we conducted two-factor crosses to compute the map distance between genes \(A\) and \(B\) and other two-factor crosses to compute the map distance between genes \(C\) and \(D\), would the calculated map distance between \(A\) and \(B\) be the same as that between \(C\) and \(D\) ? Explain.
In most two-factor crosses involving linked genes, we cannot tell if a double crossover between the two genes has occurred because the offspring will inherit the nonrecombinant pattern of alleles. How does the inability to detect double crossovers affect the calculation of map distance? Is map distance underestimated or overestimated because of our inability to detect double crossovers? Explain your answer.
Mitotic recombination can occasionally produce a twin spot. Let's suppose an animal species is heterozygous for two genes that govern fur color and length: one gene affects pigmentation, with dark pigmentation \((A)\) dominant to albino \((a)\); the other gene affects hair length, with long hair \((L)\) dominant to short hair \((I)\). The two genes are linked on the same chromosome. Let's assume an animal of this species is \(A a L l ; A\) is linked to \(I\), and \(a\) is linked to \(L\). Draw the chromosomes labeled with these alleles, and explain how mitotic recombination could produce a twin spot with one spot having albino pigmentation and long fur and the other having dark pigmentation and short fur.
When a chi square analysis is applied to solve a linkage problem, explain why an independent assortment hypothesis is proposed.
If you try to throw a basketball into a basket, the likelihood of succeeding depends on the size of the basket. It is more likely that you will get the ball into the basket if the basket is bigger. In your own words, explain how this analogy applies to the idea that the likelihood of crossing over is greater when two genes are far apart than when they are close together.
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