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Chapter 19: Problem 3

What does a suppressor mutation suppress? What is the difference between an intragenic and an intergenic suppressor?

Short Answer

Expert verified
A suppressor mutation suppresses the phenotypic effects of another mutation, 'suppressing' its effect and often restoring the original phenotype. An intragenic suppressor occurs within the same gene as the original mutation and compensates for the effect of the original mutation, usually by causing an amino acid change that restores the functionality of the protein. An intergenic suppressor, on the other hand, occurs in a different gene from where the original mutation is, and its alteration in the second gene offsets the harmful effects caused by the mutation in the first gene.

Step by step solution

01

Define Suppressor Mutation

A suppressor mutation is a second mutation that alleviates or reverts the phenotypic effects of another mutation. It compensates for the effect of the primary mutation and, in majority of cases, restores the organism's ability to synthesize a specific enzyme or perform a particular function.
02

Elucidate Intragenic Suppressor

An intragenic suppressor, as the name suggests, occurs within the same gene that carries the original mutation. It may involve a change in a different nucleotide of the same gene that somehow compensates for the effect of the original mutation 鈥� most likely by resulting in an amino acid change that restores the ability of the protein to carry out its function.
03

Clarify Intergenic Suppressor

An intergenic suppressor mutation occurs in a different gene altogether from the one that carries the original mutation. The mutation in the second gene compensates for the detrimental effects of the mutation in the first gene, resulting in a net no change in the phenotype.

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Most popular questions from this chapter

Which of the folloving examples is likely to be caused by a somatic mutation? A. A purple flower has a small patch of white tissue. B. One child, in a famsily of seven, is an albino. C One apple tree, in a very large orchart, poduces its apples 2 weeks earlier than any of the other trees. D. A 60 -year-old smoker develops lung cancer.

An individual carries a somatic mutation that changes a lysine codon into a glutamic acid codon. Prior to acquiring this mutation, the incinvidual had been exposed to UV light, proxflavin, and 5-bromouracil. Which of these three agents would be the most likely to have caused this somatic mutation? Explain your answer.

Give an example of a mulagen that can change cytosine to uracil. Which DNA repair system(s) would be able to repair this defect?

A gene mutation changes an AT base pair to GC. This change causes a gene to encode a truncated protein that is nonfunctional. An organism that carries this mutation cannot survive at high temperatures. Make a list of all the genetic terms that could be used to describe this type of mutation.

In Chapters 12 through 16 , we discussed many sequences that are outside a coding sequence but are important for gene expression. Look up two of these sequences and write them out. Explain how a mutation could change these sequences, thereby altering gene expression.
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