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Chapter 12: Problem 8

A mutation within a gene sequence changes the start codon to a stop codon. How will this mutation affect the transcription of this gene?

Short Answer

Expert verified
The mutation changing the start codon into a stop codon will stop the transcription process almost as soon as it starts, leading to the gene not being converted into a protein.

Step by step solution

01

Understanding the Basics

In genes, a start codon marks the site at which translation into protein sequence begins, and a stop codon marks the site at which translation ends. The start codon always codes for methionine in eukaryotes and a modified Met (fMet) in prokaryotes. The three stop codons do not code for an amino acid.
02

Understanding the Effect of Mutation

Now, what will happen if start codon is mutated to a stop codon? It means, immediately as transcription starts, it will also stop. Because the stop codon will signal the termination of this process before it even really started. Hence, the gene couldn't be translated to a protein.
03

Summary of the Consequence

This mutation will effectively render the entire gene non-functional as it will not be transcribed into mRNA and thus would not be translated.

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Most popular questions from this chapter

What is the function of a splicing factor? Explain how splicing factors can regulate the cell-specific splicing of mRNAs.

Describe the structure and function of a spliceosome. Speculate why the spliceosome subunits contain snRNA. In other words, what do you think is/are the functional role(s) of snRNA during splicing?

In eukaryotes, what types of modifications occur to pre-mRNAs?

Discuss the similarities and differences between RNA polymerase (described in this chapter) and DNA polymerase (described in Chapter 11).

What is the consensus sequence of the following six DNA sequences? GGCATTGACT GCCATTGTCA CGCATAGTCA GGAAATGGGA GGCTTTGTCA GGCATAGTCA
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