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If a sene in a particular chromosome has a probability of mutation of \(5 \times 10^{-5}\) per generation, and if the allele in a particular chromosome is followed through successive generations. (a) What is the probability that the allele does not undergo a mutation in 10,000 consecutive generations? (b) What is the average number of generations before the allele undergoes a mutation?

Short Answer

Expert verified
(a) \( \approx 0.60653 \), (b) 20,000 generations.

Step by step solution

01

Introduction

We are given the probability of a gene mutating in a chromosome per generation as \( p = 5 \times 10^{-5} \). We need to find the probability that no mutation occurs over 10,000 generations and the average number of generations until the first mutation occurs.
02

Probability No Mutation in One Generation

The probability of the allele not mutating in one generation is the complement of the mutation probability: \( 1 - p = 1 - 5 \times 10^{-5} = 0.99995 \).
03

Probability No Mutation in 10,000 Generations

The probability that the allele does not undergo a mutation over 10,000 consecutive generations can be calculated using the formula for successive independent events: \( (1-p)^n = (0.99995)^{10000} \).
04

Calculate the Probability

By calculating \( (0.99995)^{10000} \), we find this probability using a calculator: \( (0.99995)^{10000} \approx 0.60653 \).
05

Average Generations Until Mutation

The average number of generations before the first mutation occurs is the reciprocal of the mutation probability, given by \( \frac{1}{p} = \frac{1}{5 \times 10^{-5}} = 20000 \).
06

Conclusion

We have calculated the probability of no mutation for 10,000 generations and the expected number of generations until a mutation occurs.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Successive Generations
In genetic studies, especially in the context of mutations, the concept of successive generations plays a crucial role. When we talk about successive generations, we refer to the repeated cycle of gene transmission from one generation to another.

In each generation, genetic material is passed down from parents to offspring. During this process, there is always a probability that mutations can occur. A mutation is simply a change in the DNA sequence which can alter gene function.

  • Every generation provides another chance for mutations.
  • The study of successive generations helps predict how traits or mutations may appear across several generations.
  • Understanding successive generations allows scientists to model genetic change over time.
In the exercise, the mutation probability is considered for each new generation, thus requiring us to calculate events occurring across multiple generations. By calculating such probabilities over several generations, one can better understand how frequently or rarely an event, like a mutation, might occur.
Allele Mutation
An allele is a variant form of a gene. Imagine genes as books containing instructions for making a living organism. Alleles are like different versions of this book, providing various details. Mutation refers to a change, often a random change, in this allele, which alters its structure.

  • Mutations can be caused by various factors such as environmental, chemical, or even random errors during DNA replication.
  • Mutations can have no effect, a deleterious effect, or sometimes even a beneficial effect on the organism.
  • The probability of mutation in the exercise is very small, but given enough generations, even rare events may occur.
The alleles in focus can proceed through successive generations without mutation or can undergo a mutation that might lead to genetic diversity. In genetics, understanding allele mutation helps us learn about genetic diseases, evolution, and even conservations strategies for endangered species based on genetic variation.
Average Generations Before Mutation
To understand the average generations before a mutation, we consider how often, on average, a specific event happens. Here, the event is a mutation, occurring with a small probability each generation.

The average number of generations before a mutation occurs is calculated as the reciprocal of the probability of mutation. This tells us how many generations one can typically expect before such a rare event takes place.

  • The calculation is straightforward: if the mutation probability is low, like in the exercise, then the expected number of generations before mutation is quite high.
  • This concept helps in understanding the scale or frequency of genetic change.
  • In the exercise, with a mutation probability of \(5 \times 10^{-5}\), one expects on average 20,000 generations before a mutation occurs.
Knowing the average generations before mutation can provide insights into the dynamics of population genetics. It allows scientists to make predictions and emphasize the rarity yet the eventual possibility of mutations, shaping the genetic makeup of future generations.

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Most popular questions from this chapter

Among several hundred missense mutations in the gene for the A protein of tryptophan synthase in E. wli, fewer than 30 of the 268 amino add positions are affected by one or more mutations. Explain why the number of positions affected by amino acid replacements is 50 low.

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This problem ithustrates how conditional mutations can be used to determine the order of genetically cuntrolled steps in a developmental pathway. A certain organ undergoes development in the sequence of stages \(\mathrm{A} \rightarrow \mathrm{B}\) \(\rightarrow \mathrm{C}\), and both gene \(X\) and gene \(Y\) are necessary for the sequence to procecd. A conditional mutation \(X^{\prime}\) is sensitive to heat (the gene product is inactivated at high temperatures), and a conditional mutation \(\gamma^{\prime}\) is sensitive to cold ithe gene product is inactivated at cold temperatures). The double mutant \(X^{\prime}\left(X^{\prime} Y^{\prime} / Y^{\prime}\right.\) is created and reared at cither high or low temperatures. How far would development proceed in each of the following cases at the high temperature and at the low temperature? (a) Both \(X\) and \(Y\) are necessary for the \(\mathrm{A} \rightarrow \mathrm{B}\) step. (b) Both \(X\) and \(Y\) are necessary for the \(B \rightarrow C\) step. (c) \(X\) is necessary for the \(\mathrm{A} \rightarrow \mathrm{B}\) step, and \(Y\) for the \(\mathrm{B} \rightarrow\) C step. (d) \(Y\) is necessary for the \(\mathrm{A} \rightarrow \mathrm{B}\) step, and \(X\) for the \(\mathrm{B} \rightarrow\) C.step.

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