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91Ó°ÊÓ

Assume that long ear lobes in humans are an autosomal dominant trait that exhibits \(30 \%\) penetrance. A person who is heterozygous for long ear lobes mates with a person who is homozygous for normal ear lobes. What is the probability that their first child will have long ear lobes?

Short Answer

Expert verified
15% probability the child will have long ear lobes.

Step by step solution

01

Determine Genotypes of the Parents

The person who is heterozygous for long ear lobes has one dominant allele (L) and one recessive allele (l), so their genotype is Ll. The person who is homozygous for normal ear lobes has two recessive alleles (l), so their genotype is ll.
02

Determine Possible Genotypes of the Child

Using a Punnett square, we can find the potential genotypes of the child. When one parent is Ll and the other is ll, the possible genotypes for the child are Ll and ll. There is a 50% chance for each genotype.
03

Determine Phenotypes from Genotypes

For the child to have long ear lobes, their genotype must include the dominant allele (L). Based on Step 2, there is a 50% probability that the child will be Ll, which would result in the phenotype of long ear lobes.
04

Apply the Penetrance Factor

Penetrance is the probability that a genotype will result in a phenotype. Here, long ear lobes have a 30% penetrance, meaning only 30% of those with the Ll genotype exhibit long ear lobes. Multiply the probability of the child having the Ll genotype (50%) by the penetrance (30%) to find the probability the child will phenotypically have long ear lobes.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Autosomal Dominant
In genetics, when we talk about traits, we look at how they are inherited. An autosomal dominant trait means you only need one copy of the dominant allele to show the trait. **Think of it like a switch**: Only one 'on' switch is necessary to turn on the trait. For example, if 'L' represents the dominant allele for long ear lobes, a person with at least one 'L' allele (like Ll or LL) will have long ear lobes.

This is because autosomal dominant traits are located on the autosomes, the numbered chromosomes, which are inherited equally from both parents. They aren't related to the sex chromosomes, so they affect males and females equally. This type of inheritance means that if one parent has a dominant trait, there's a chance they can pass it down to their children just by chance.
Punnett Square
The Punnett square is a simple yet powerful tool in genetics to predict possible genotypes of offspring from parental genes. It's like a genetic probability chart. You place the alleles from one parent on the top, and the alleles from the other parent on the side, and fill in the squares.

For instance, in our original problem, the Punnett square helps us see that when a heterozygous (Ll) individual mates with a homozygous recessive (ll) individual, their child can either be Ll or ll.
  • Ll - would result in long ear lobes
  • ll - would result in normal ear lobes
Both genotypes have a 50% chance of occurring. This visual breakdown is essential for grasping the probability of different genetic outcomes.
Penetrance
Penetrance is an interesting concept in genetics that describes how often a genotype results in the expected phenotype. If an autosomal dominant trait, like long ear lobes, has a penetrance of 30%, then only 30% of those carrying the dominant gene actually exhibit the trait.

This means that even if a child inherits the dominant allele for long ear lobes, they won't always show it. You multiply the chances of having the trait by its penetrance to get the actual probability of exhibiting it. In our case, a 50% chance of Ll genotype results in a child actually showing long ear lobes only 15% of the time (50% times 30%). This nuance shows how real-world genetics can be quite intricate!
Homozygous and Heterozygous
These terms describe the genetic makeup regarding a specific trait. **Homozygous** means the individual has two identical alleles for a trait. For someone with normal ear lobes (ll), they are homozygous recessive.

**Heterozygous** means the individual has two different alleles for a trait. In our context, a person with long ear lobes but carrying different alleles (Ll) is heterozygous.
  • Homozygous: Identical Alleles (LL or ll)
  • Heterozygous: Different Alleles (Ll)
Understanding these terms is crucial because they dictate the possible genetic outcomes when it comes to traits. Whether a trait is expressed can depend heavily on these genetic configurations.

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Most popular questions from this chapter

What is incomplete penetrance, and what causes it?

What is the difference between a sex-influenced gene and a gene that exhibits genomic imprinting?

In chickens, comb shape is determined by alleles at two loci \((R, r\) and \(P, p)\). A walnut comb is produced when at least one dominant allele \(R\) is present at one locus and at least one dominant allele \(P\) is present at a second locus (genotype \(\left.R_{-} P_{-}\right) .\) A rose comb is produced when at least one dominant allele is present at the first locus and two recessive alleles are present at the second locus (genotype \(\left.R_{-} p p\right)\). A pea comb is produced when two recessive alleles are present at the first locus and at least one dominant allele is present at the second (genotype \(r r P_{-}\) ). If two recessive alleles are present at the first and at the second loci \((r r p p)\), a single comb is produced. Progeny with what types of combs and in what proportions will result from the following crosses? a. \(R R \space P P \times \operatorname{rr}\space p p\) b. \(\operatorname{Rr} P p \times \operatorname{rrpp}\) c. \(\operatorname{Rr} P p \times \operatorname{Rr} P p\) d. \(\operatorname{Rr} p p \times \operatorname{Rr} p p\) e. \(\operatorname{Rr} p p \times \operatorname{rr} \mathrm{Pp}\) f. \(\operatorname{Rr} p p \times \operatorname{rrpp}\)

Which of the following statements describes an example of a phenocopy? Explain your reasoning. a. Phenylketonuria results from a recessive mutation that causes light skin as well as intellectual disability. b. Human height is influenced by genes at many different loci. c. Dwarf plants and mottled leaves in tomatoes are caused by separate genes that are linked. d. Vestigial wings in Drosophila are produced by a recessive mutation. This trait is also produced by high temperature during development. e. Intelligence in humans is influenced by both genetic and environmental factors.

What is genomic imprinting?

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