Chapter 7: Problem 7
Explain the meaning of the term interference.
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Chapter 7: Problem 7
Explain the meaning of the term interference.
These are the key concepts you need to understand to accurately answer the question.
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Three loci, mitochondrial malate dehydrogenase that forms \(a\) and \(b(M D H a, M D H b),\) glucouronidase that forms 1 and \(2(G U S 1\) \(G U S 2\) ), and a histone gene that forms \(+\) and \(-(H+, H-),\) are located on chromosome \(\\# 7\) in humans. Assume that the \(M D H\) locus is at position \(35, G U S\) at position \(45,\) and \(H\) at position 75 A female whose mother was homozygous for \(M D H a, G U S 2,\) and \(H+\) and whose father was homozygous for \(M D H b, G U S 1,\) and \(H-\) produces a sample of 1000 egg cells. Give the genotypes and expected numbers of the various types of cells she would produce. Assume no chromosomal interference.
What three essential criteria must be met in order to execute a successful mapping cross?
Are sister chromatid exchanges effective in producing genetic variability in an individual? in the offspring of individuals?
In the fruit fly, Drosophila melanogaster, a spineless (no wing bristles) female fly is mated to a male that is claret (dark eyes) and hairless (no thoracic bristles). Phenotypically wild-type \(\mathrm{F}_{1}\) female progeny were mated to fully homozygous (mutant) males, and the following progeny ( 1000 total) were observed: $$\begin{array}{lc} \text { Phenotypes } & \text { Number Observed } \\ \hline \text { spineless } & 321 \\ \text { wild } & 38 \\ \text { claret, spineless } & 130 \\ \text { claret } & 18 \\ \text { claret, hairless } & 309 \\ \text { hairless, claret, spineless } & 32 \\ \text { hairless } & 140 \\ \text { hairless, spineless } & 12 \end{array}$$ (a) Which gene is in the middle? (b) With respect to the three genes mentioned in the problem, what are the genotypes of the homozygous parents used in making the phenotypically wild \(F_{1}\) heterozygote? (c) What are the map distances between the three genes? A correct formula with the values "plugged in" for each distance will be sufficient. (d) What is the coefficient of coincidence? A correct formula with the values "plugged in" will be sufficient.
Why does more crossing over occur between two distantly linked genes than between two genes that are very close together on the same chromosome?
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