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Natural selection is such a powerful force in evolution because organisms or cells with even a small reproductive advantage will eventually outnumber their competitors. To illustrate how quickly this process can occur, consider a cell culture that contains 1 million bacterial cells that double every 20 minutes. A single cell in this culture acquires a mutation that allows it to divide faster, with a generation time of only 15 minutes. Assuming that there is an unlimited food supply and no cell death, how long would it take before the progeny of the mutated cell became predominant in the culture? (Before you go through the calculation, make a guess: do you think it would take about a day, a week, a month, or a year?) How many cells of either type are present in the culture at this time? (The number of cells \(N\) in the culture at time \(t\) is described by the equation \(N=N_{0} \times 2^{t / G},\) where \(N_{0}\) is the number of cells at zero time and \(G\) is the generation time.

Short Answer

Expert verified
The mutant cells become predominant after 1200 minutes.

Step by step solution

01

Establish Initial Conditions

The initial number of cells in the culture is 1 million, or \(N_0 = 1,000,000\). The generation time \(G\) for normal cells is 20 minutes and for mutant cells is 15 minutes. We will compare the growth of both populations over time to determine when the mutant cells become predominant.
02

Define Equations for Cell Growth

The general formula for cell growth is given by \(N = N_0 \times 2^{t/G}\). For normal cells, the equation becomes \(N_n = 1,000,000 \times 2^{t/20}\). For the mutant cells, the equation becomes \(N_m = 1 \times 2^{t/15}\), since the mutation starts from a single cell.
03

Determine Population Equality

To find when mutant cells become predominant, we first find when they equal the normal cells. Set the equations equal: \[ 1,000,000 \times 2^{t/20} = 1 \times 2^{t/15} \]Simplify by dividing both sides by 1,000,000:\[ 2^{t/20} = 2^{t/15}/1,000,000 \]
04

Solve for Time

Equate the exponents since the base (2) is the same, leading to:\[ \frac{t}{20} = \frac{t}{15} - 20 \]Solve the equation for \(t\):Multiply through by 60 to clear fractions:\[ 3t = 4t - 1200 \]Simplify:\[ 1200 = t \]It takes 1200 minutes for the mutant cells to become predominant.
05

Calculate Number of Cells at Predominance Time

Substitute \(t = 1200\) minutes into the normal and mutant cell equations to find their populations.For normal cells:\[ N_n = 1,000,000 \times 2^{1200/20} = 1,000,000 \times 2^{60} \]For mutant cells:\[ N_m = 1 \times 2^{1200/15} = 1 \times 2^{80} \]
06

Complete Numerical Calculations

Calculate the actual numbers:Normal Cells: \[ N_n = 1,099,511,627,776 \] (approximately 1 trillion)Mutant Cells:\[ N_m = 1,208,925,819,614,629,174,706,176 \] (approximately 1 sextillion)Mutant cells exceed normal cells, confirming predominance.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

Bacterial Cell Division
Bacteria primarily reproduce through a process called binary fission. This is where a single bacterial cell divides into two identical offspring. It's a straightforward process and remarkably efficient. During binary fission, the bacterial DNA replicates, and the cell's components are doubled. These include the membrane and cytoplasm. Then, a septum forms, dividing the cell into two new cells that are genetically identical to the original. This method allows bacteria to rapidly increase their numbers, especially when the environment is favorable.

Specific factors like temperature, nutrient availability, and environmental conditions can influence the rate of bacterial division. Under optimal conditions, some bacteria can divide every 20 minutes. However, this rate can greatly vary among different bacterial species. Understanding this process is crucial in both studying ecology and managing bacterial growth in medical or industrial settings.
Mutations in Evolution
Mutations are changes in the genetic material of an organism and play a crucial role in evolution. They can occur due to errors in DNA replication or through environmental factors like radiation. Most mutations are neutral or harmful to bacteria, but occasionally a mutation can provide an advantage.

For instance, in the case of the mutated bacterial cell from the problem, a mutation allowed it to divide faster than its counterparts. This improved ability to reproduce more frequently gave it a competitive edge, allowing it to become predominant over time. Mutations can lead to natural selection, where advantageous traits become more common in a population. This process is a fundamental component of evolutionary biology and helps explain how organisms adapt to their environments.

Over generations, advantageous mutations can lead to significant changes in a species, sometimes even the creation of new species. This ties back to why natural selection is such a powerful force in evolution.
Generation Time Calculation
Generation time is a measure of how quickly a population of organisms can double in number. It's an important concept in microbiology, particularly when studying bacteria. In the exercise, the generation time is defined by the variable \( G \). For instance, normal bacterial cells have a generation time of 20 minutes, while a mutated cell divides every 15 minutes.

To calculate the number of cells at any given time, you can use the formula:
  • \( N = N_{0} \times 2^{t/G} \)
Where:
  • \( N \) is the number of cells at time \( t \)
  • \( N_{0} \) is the initial number of cells
  • \( G \) is the generation time
This formula shows how rapidly populations can grow when given optimal conditions. For the mutated cells in the exercise, the generation time is shorter, leading to faster population growth compared to the normal cells. Such calculations are vital for predicting bacterial growth in cultures and managing conditions for industrial microbiology applications or controlling infections.

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Most popular questions from this chapter

Mutations are mistakes in the DNA that change the genetic plan from that of the previous generation. Imagine a shoe factory. Would you expect mistakes (i.e., unintentional changes in copying the shoe design to lead to improvements in the shoes produced? Explain your answer.

There are three major classes of protein filaments that make up the cytoskeleton of a typical animal cell. What are they, and what are the differences in their functions? Which cytoskeletal filaments would be most plentiful in a muscle cell or in an epidermal cell making up the outer layer of the skin? Explain your answers.

"The structure and function of a living cell are dictated by the laws of chemistry, physics, and thermodynamics." Provide examples that support (or refute) this claim.

When bacteria are cultured under adverse conditions-for example, in the presence of a poison such as an antibioticmost cells grow and divide slowly. But it is not uncommon to find that the rate of proliferation is restored to normal after a few days. Suggest why this may be the case.

Which of the following statements are correct? Explain your answers. A. The hereditary information of a cell is passed on by its proteins. B. Bacterial DNA is found in the cytoplasm. C. Plants are composed of prokaryotic cells. D. With the exception of egg and sperm cells, all of the nucleated cells within a single multicellular organism have the same number of chromosomes. E. The cytosol includes membrane-enclosed organelles such as lysosomes. F. The nucleus and a mitochondrion are each surrounded by a double membrane. G. Protozoans are complex organisms with a set of specialized cells that form tissues such as flagella, mouthparts, stinging darts, and leglike appendages. H. Lysosomes and peroxisomes are the sites of degradation of unwanted materials.

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